Abstract
The early events in neoplastic transformation can be understood only by comparison of the neoplastic cell with its nontransformed counterpart. The most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined the possibility that gliomas arise from a population of glia that has properties of oligodendrocyte progenitors. These glial cells express the NG2 chondroitin sulfate proteoglycan and the α receptor of platelet-derived growth factor in vivo. We identified NG2 and the a receptor of platelet-derived growth factor expression in tissue from seven of seven oligodendrogliomas, three of three pilocytic astrocytomas, and one of five glioblastoma multiforme. These data provide evidence that glial tumors arise from glial progenitor cells. Molecules expressed by these progenitor cells should be considered as targets for novel therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10361-10366 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 96 |
| Issue number | 18 |
| DOIs | |
| State | Published - Aug 31 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
Expression of oligodendrocyte progenitor cell antigens by gliomas : Implications for the histogenesis of brain tumors. / Shoshan, Yigal; Nishiyama, Akiko; Chang, Ansi; Mörk, Sverre; Barnetti, Gene H.; Cowell, John Kenneth; Trapp, Bruce D.; Staugaitis, Susan M.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 18, 31.08.1999, p. 10361-10366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of oligodendrocyte progenitor cell antigens by gliomas
T2 - Implications for the histogenesis of brain tumors
AU - Shoshan, Yigal
AU - Nishiyama, Akiko
AU - Chang, Ansi
AU - Mörk, Sverre
AU - Barnetti, Gene H.
AU - Cowell, John Kenneth
AU - Trapp, Bruce D.
AU - Staugaitis, Susan M.
PY - 1999/8/31
Y1 - 1999/8/31
N2 - The early events in neoplastic transformation can be understood only by comparison of the neoplastic cell with its nontransformed counterpart. The most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined the possibility that gliomas arise from a population of glia that has properties of oligodendrocyte progenitors. These glial cells express the NG2 chondroitin sulfate proteoglycan and the α receptor of platelet-derived growth factor in vivo. We identified NG2 and the a receptor of platelet-derived growth factor expression in tissue from seven of seven oligodendrogliomas, three of three pilocytic astrocytomas, and one of five glioblastoma multiforme. These data provide evidence that glial tumors arise from glial progenitor cells. Molecules expressed by these progenitor cells should be considered as targets for novel therapeutics.
AB - The early events in neoplastic transformation can be understood only by comparison of the neoplastic cell with its nontransformed counterpart. The most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined the possibility that gliomas arise from a population of glia that has properties of oligodendrocyte progenitors. These glial cells express the NG2 chondroitin sulfate proteoglycan and the α receptor of platelet-derived growth factor in vivo. We identified NG2 and the a receptor of platelet-derived growth factor expression in tissue from seven of seven oligodendrogliomas, three of three pilocytic astrocytomas, and one of five glioblastoma multiforme. These data provide evidence that glial tumors arise from glial progenitor cells. Molecules expressed by these progenitor cells should be considered as targets for novel therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=0033621190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033621190&partnerID=8YFLogxK
U2 - 10.1073/pnas.96.18.10361
DO - 10.1073/pnas.96.18.10361
M3 - Article
VL - 96
SP - 10361
EP - 10366
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 18
ER -