Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

Yigal Shoshan, Akiko Nishiyama, Ansi Chang, Sverre Mörk, Gene H. Barnetti, John K. Cowell, Bruce D. Trapp, Susan M. Staugaitis

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The early events in neoplastic transformation can be understood only by comparison of the neoplastic cell with its nontransformed counterpart. The most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined the possibility that gliomas arise from a population of glia that has properties of oligodendrocyte progenitors. These glial cells express the NG2 chondroitin sulfate proteoglycan and the α receptor of platelet-derived growth factor in vivo. We identified NG2 and the a receptor of platelet-derived growth factor expression in tissue from seven of seven oligodendrogliomas, three of three pilocytic astrocytomas, and one of five glioblastoma multiforme. These data provide evidence that glial tumors arise from glial progenitor cells. Molecules expressed by these progenitor cells should be considered as targets for novel therapeutics.

Original languageEnglish (US)
Pages (from-to)10361-10366
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number18
DOIs
StatePublished - Aug 31 1999

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Oligodendroglia
Brain Neoplasms
Glioma
Neuroglia
Stem Cells
Antigens
Platelet-Derived Growth Factor Receptors
Chondroitin Sulfate Proteoglycans
Oligodendroglioma
Astrocytoma
Glioblastoma
Astrocytes
Central Nervous System
Population
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Genetics
  • General

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Expression of oligodendrocyte progenitor cell antigens by gliomas : Implications for the histogenesis of brain tumors. / Shoshan, Yigal; Nishiyama, Akiko; Chang, Ansi; Mörk, Sverre; Barnetti, Gene H.; Cowell, John K.; Trapp, Bruce D.; Staugaitis, Susan M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 18, 31.08.1999, p. 10361-10366.

Research output: Contribution to journalArticle

Shoshan, Yigal ; Nishiyama, Akiko ; Chang, Ansi ; Mörk, Sverre ; Barnetti, Gene H. ; Cowell, John K. ; Trapp, Bruce D. ; Staugaitis, Susan M. / Expression of oligodendrocyte progenitor cell antigens by gliomas : Implications for the histogenesis of brain tumors. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 18. pp. 10361-10366.
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