Abstract
Sproutys and Sprouty-related proteins, Spred-1 and -2, are known inhibitors of fibroblast growth factor (FGF) signaling, which plays key role in lung branching morphogenesis and the development of other tissues. The present study demonstrates that Spreds are expressed in a variety of rat embryonic tissues (brain, intestine, heart, skin) including the lung. In the embryonic lung, Spreds and Sproutys are expressed during the early stages of branching morphogenesis, but their expression profiles are both distinct and overlapping. Spreds are predominantly expressed in mesenchymal cells in contrast to Sproutys, which are abundantly expressed in epithelial cells. Spred expression is especially strong in the regions of new bud formation both in the peripheral mesenchyme as well as in the epithelium. The peripheral region also expresses FGF-10 in the mesenchymal cells and FGF-9 in the mesothelial cells. The expression profiles suggest that Spreds, Sproutys and FGF-9/FGF-10 are part of epithelial-mesenchymal interactions, which are essential for the development and maintenance of normal lung branching pattern.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 347-353 |
| Number of pages | 7 |
| Journal | Gene Expression Patterns |
| Volume | 2 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Dec 1 2002 |
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Keywords
- CC10
- FGF-10
- Lung branching morphogenesis
- SP-C
- Spred
- Sprouty
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Developmental Biology
Cite this
Expression of Spred and Sprouty in developing rat lung. / Hashimoto, Shuichi; Nakano, Hiroshi; Singh, Gurmukh; Katyal, Sikandar.
In: Gene Expression Patterns, Vol. 2, No. 3-4, 01.12.2002, p. 347-353.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of Spred and Sprouty in developing rat lung
AU - Hashimoto, Shuichi
AU - Nakano, Hiroshi
AU - Singh, Gurmukh
AU - Katyal, Sikandar
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Sproutys and Sprouty-related proteins, Spred-1 and -2, are known inhibitors of fibroblast growth factor (FGF) signaling, which plays key role in lung branching morphogenesis and the development of other tissues. The present study demonstrates that Spreds are expressed in a variety of rat embryonic tissues (brain, intestine, heart, skin) including the lung. In the embryonic lung, Spreds and Sproutys are expressed during the early stages of branching morphogenesis, but their expression profiles are both distinct and overlapping. Spreds are predominantly expressed in mesenchymal cells in contrast to Sproutys, which are abundantly expressed in epithelial cells. Spred expression is especially strong in the regions of new bud formation both in the peripheral mesenchyme as well as in the epithelium. The peripheral region also expresses FGF-10 in the mesenchymal cells and FGF-9 in the mesothelial cells. The expression profiles suggest that Spreds, Sproutys and FGF-9/FGF-10 are part of epithelial-mesenchymal interactions, which are essential for the development and maintenance of normal lung branching pattern.
AB - Sproutys and Sprouty-related proteins, Spred-1 and -2, are known inhibitors of fibroblast growth factor (FGF) signaling, which plays key role in lung branching morphogenesis and the development of other tissues. The present study demonstrates that Spreds are expressed in a variety of rat embryonic tissues (brain, intestine, heart, skin) including the lung. In the embryonic lung, Spreds and Sproutys are expressed during the early stages of branching morphogenesis, but their expression profiles are both distinct and overlapping. Spreds are predominantly expressed in mesenchymal cells in contrast to Sproutys, which are abundantly expressed in epithelial cells. Spred expression is especially strong in the regions of new bud formation both in the peripheral mesenchyme as well as in the epithelium. The peripheral region also expresses FGF-10 in the mesenchymal cells and FGF-9 in the mesothelial cells. The expression profiles suggest that Spreds, Sproutys and FGF-9/FGF-10 are part of epithelial-mesenchymal interactions, which are essential for the development and maintenance of normal lung branching pattern.
KW - CC10
KW - FGF-10
KW - Lung branching morphogenesis
KW - SP-C
KW - Spred
KW - Sprouty
UR - http://www.scopus.com/inward/record.url?scp=0036955833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036955833&partnerID=8YFLogxK
U2 - 10.1016/S1567-133X(02)00053-4
DO - 10.1016/S1567-133X(02)00053-4
M3 - Article
C2 - 12617824
AN - SCOPUS:0036955833
VL - 2
SP - 347
EP - 353
JO - Brain research. Gene expression patterns
JF - Brain research. Gene expression patterns
SN - 1567-133X
IS - 3-4
ER -