Abstract
Objectives: To determine the effects of low-dose external beam irradiation compared with observation on the visual function of eyes with subfoveal choroidal neovascularization (CNV) complicating age-related macular degeneration (ARMD). Design: Prospective, double-masked, randomized clinical trial. Patients randomized to the radiation group received external beam irradiation at a dose of 14 Gy in 7 fractions of 2 Gy. Patients randomized to the observation group received sham radiation. Setting: Tertiary care retinal referral practice. Patients: Individuals with classic, mixed, or occult subfoveal CNV secondary to ARMD. Main Outcome Measures: Change in visual acuity from baseline to specified time periods. Secondary outcome variables were contrast sensitivity and fundus photographic/fluorescein angiographic progression. Results: Forty-two eyes were randomized to observation; 41 eyes, to radiation. Baseline characteristics and demographics did not differ between groups. The median distance visual acuity (DVA) in radiation-treated eyes decreased from 20/80 at baseline to 20/320 (mean loss rate, 4.14 lines) at 1-year follow-up. The median DVA in observation group eyes decreased from 20/125 at baseline to 20/250 (mean loss rate, 3.39 lines) at 1-year follow-up. There were no statistically significant differences in changes in DVA, contrast sensitivity, or fluorescein angiographic progression from baseline between groups at any follow-up period. Conclusions: At 1-year follow-up, low-dose external beam irradiation at 14 Gy in 7 fractions of 2 Gy is neither beneficial nor harmful for subfoveal CNV complicating ARMD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-180 |
| Number of pages | 10 |
| Journal | Archives of Ophthalmology |
| Volume | 119 |
| Issue number | 2 |
| State | Published - Feb 22 2001 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
External beam irradiation of subfoveal choroidal neovascularization complicating age-related macular degeneration : One-year results of a prospective, double-masked, randomized clinical trial. / Marcus, D. M.; Sheils, W. C.; Johnson, M. H.; McIntosh, S. B.; Leibach, D. B.; Maguire, A.; Alexander, J.; Samy, C. N.
In: Archives of Ophthalmology, Vol. 119, No. 2, 22.02.2001, p. 171-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - External beam irradiation of subfoveal choroidal neovascularization complicating age-related macular degeneration
T2 - One-year results of a prospective, double-masked, randomized clinical trial
AU - Marcus, D. M.
AU - Sheils, W. C.
AU - Johnson, M. H.
AU - McIntosh, S. B.
AU - Leibach, D. B.
AU - Maguire, A.
AU - Alexander, J.
AU - Samy, C. N.
PY - 2001/2/22
Y1 - 2001/2/22
N2 - Objectives: To determine the effects of low-dose external beam irradiation compared with observation on the visual function of eyes with subfoveal choroidal neovascularization (CNV) complicating age-related macular degeneration (ARMD). Design: Prospective, double-masked, randomized clinical trial. Patients randomized to the radiation group received external beam irradiation at a dose of 14 Gy in 7 fractions of 2 Gy. Patients randomized to the observation group received sham radiation. Setting: Tertiary care retinal referral practice. Patients: Individuals with classic, mixed, or occult subfoveal CNV secondary to ARMD. Main Outcome Measures: Change in visual acuity from baseline to specified time periods. Secondary outcome variables were contrast sensitivity and fundus photographic/fluorescein angiographic progression. Results: Forty-two eyes were randomized to observation; 41 eyes, to radiation. Baseline characteristics and demographics did not differ between groups. The median distance visual acuity (DVA) in radiation-treated eyes decreased from 20/80 at baseline to 20/320 (mean loss rate, 4.14 lines) at 1-year follow-up. The median DVA in observation group eyes decreased from 20/125 at baseline to 20/250 (mean loss rate, 3.39 lines) at 1-year follow-up. There were no statistically significant differences in changes in DVA, contrast sensitivity, or fluorescein angiographic progression from baseline between groups at any follow-up period. Conclusions: At 1-year follow-up, low-dose external beam irradiation at 14 Gy in 7 fractions of 2 Gy is neither beneficial nor harmful for subfoveal CNV complicating ARMD.
AB - Objectives: To determine the effects of low-dose external beam irradiation compared with observation on the visual function of eyes with subfoveal choroidal neovascularization (CNV) complicating age-related macular degeneration (ARMD). Design: Prospective, double-masked, randomized clinical trial. Patients randomized to the radiation group received external beam irradiation at a dose of 14 Gy in 7 fractions of 2 Gy. Patients randomized to the observation group received sham radiation. Setting: Tertiary care retinal referral practice. Patients: Individuals with classic, mixed, or occult subfoveal CNV secondary to ARMD. Main Outcome Measures: Change in visual acuity from baseline to specified time periods. Secondary outcome variables were contrast sensitivity and fundus photographic/fluorescein angiographic progression. Results: Forty-two eyes were randomized to observation; 41 eyes, to radiation. Baseline characteristics and demographics did not differ between groups. The median distance visual acuity (DVA) in radiation-treated eyes decreased from 20/80 at baseline to 20/320 (mean loss rate, 4.14 lines) at 1-year follow-up. The median DVA in observation group eyes decreased from 20/125 at baseline to 20/250 (mean loss rate, 3.39 lines) at 1-year follow-up. There were no statistically significant differences in changes in DVA, contrast sensitivity, or fluorescein angiographic progression from baseline between groups at any follow-up period. Conclusions: At 1-year follow-up, low-dose external beam irradiation at 14 Gy in 7 fractions of 2 Gy is neither beneficial nor harmful for subfoveal CNV complicating ARMD.
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M3 - Article
C2 - 11176977
AN - SCOPUS:0035128938
VL - 119
SP - 171
EP - 180
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 2
ER -