Extracavitary manifestation of primary effusion lymphoma as a right atrial mass

Creticus P. Marak, Ana M. Ponea, Chang Shim, Shagufta Shaheen, Achuta Kumar Guddati

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Primary effusion lymphoma (PEL) is a subset of large B cell lymphomas and has been mostly associated with human immunodeficiency virus infection. Rare cases have been reported in organ transplant recipients and chronic hepatitis C patients. It typically presents as an effusion in the pleural and pericardial spaces but rarely disseminates. However, involvement of the gastrointestinal tract, lymph nodes and bone marrow has been reported. Diagnosis is based on characteristic clinical, histopathological and immunohistochemical features. We present a case with a right atrial mass which tested positive for human herpes virus 8 (HHV-8), CD20, CD30 and lambda light chains and negative for CD138, kappa light chain, PAX5, Epstein-Barr virus, latent membrane protein 1, CD2, CD3, CD8 and CD56. Bilateral pleural effusions and pericardial effusions were noted which tested positive for HHV-8, CD30 and CD45. The patient responded well to the R-EPOCH regimen with complete resolution of the effusions and a significant decrease in the size of the right atrial mass. This case report illustrates the atypical manifestation of PEL as a right atrial mass.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalCase Reports in Oncology
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Primary Effusion Lymphoma
Pleural Effusion
Viruses
Light
Pericardial Effusion
Pericardium
B-Cell Lymphoma
Chronic Hepatitis C
Virus Diseases
Gastrointestinal Tract
Lymph Nodes
Bone Marrow
HIV
Transplants

Keywords

  • Human herpes virus 8
  • Primary effusion lymphoma
  • R-EPOCH
  • Right atrial mass

ASJC Scopus subject areas

  • Oncology

Cite this

Extracavitary manifestation of primary effusion lymphoma as a right atrial mass. / Marak, Creticus P.; Ponea, Ana M.; Shim, Chang; Shaheen, Shagufta; Guddati, Achuta Kumar.

In: Case Reports in Oncology, Vol. 6, No. 1, 01.01.2013, p. 114-118.

Research output: Contribution to journalArticle

Marak, Creticus P. ; Ponea, Ana M. ; Shim, Chang ; Shaheen, Shagufta ; Guddati, Achuta Kumar. / Extracavitary manifestation of primary effusion lymphoma as a right atrial mass. In: Case Reports in Oncology. 2013 ; Vol. 6, No. 1. pp. 114-118.
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