Extracellular vesicles in diagnosis and therapy of kidney diseases

Wei Zhang, Xiangjun Zhou, Hao Zhang, Qisheng Yao, Yutao Liu, Zheng Dong

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Extracellular vesicles (EV) are endogenously produced, membrane-bound vesicles that contain various molecules. Depending on their size and origins, EVs are classified into apoptotic bodies, microvesicles, and exosomes. A fundamental function of EVs is to mediate intercellular communication. In kidneys, recent research has begun to suggest a role of EVs, especially exosomes, in cell-cell communication by transferring proteins, mRNAs, and microRNAs to recipient cells as nanovectors. EVs may mediate the cross talk between various cell types within kidneys for the maintenance of tissue homeostasis. They may also mediate the cross talk between kidneys and other organs under physiological and pathological conditions. EVs have been implicated in the pathogenesis of both acute kidney injury and chronic kidney diseases, including renal fibrosis, end-stage renal disease, glomerular diseases, and diabetic nephropathy. The release of EVs with specific molecular contents into urine and plasma may be useful biomarkers for kidney disease. In addition, EVs produced by cultured cells may have therapeutic effects for these diseases. However, the role of EVs in kidney diseases is largely unclear, and the mechanism underlying EV production and secretion remains elusive. In this review, we introduce the basics of EVs and then analyze the present information about the involvement, diagnostic value, and therapeutic potential of EVs in major kidney diseases.

Original languageEnglish (US)
Pages (from-to)F844-F851
JournalAmerican Journal of Physiology - Renal Physiology
Volume311
Issue number5
DOIs
StatePublished - Jan 1 2016

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Kidney Diseases
Exosomes
Kidney
Diabetic Nephropathies
Therapeutic Uses
Therapeutics
MicroRNAs
Chronic Renal Insufficiency
Acute Kidney Injury
Cell Communication
Chronic Kidney Failure
Cultured Cells
Homeostasis
Fibrosis
Biomarkers
Maintenance
Urine
Messenger RNA
Membranes
Extracellular Vesicles

Keywords

  • Acute kidney injury
  • Biomarker
  • Chronic kidney disease
  • Exosome
  • Therapy

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Extracellular vesicles in diagnosis and therapy of kidney diseases. / Zhang, Wei; Zhou, Xiangjun; Zhang, Hao; Yao, Qisheng; Liu, Yutao; Dong, Zheng.

In: American Journal of Physiology - Renal Physiology, Vol. 311, No. 5, 01.01.2016, p. F844-F851.

Research output: Contribution to journalReview article

Zhang, Wei ; Zhou, Xiangjun ; Zhang, Hao ; Yao, Qisheng ; Liu, Yutao ; Dong, Zheng. / Extracellular vesicles in diagnosis and therapy of kidney diseases. In: American Journal of Physiology - Renal Physiology. 2016 ; Vol. 311, No. 5. pp. F844-F851.
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