Extreme Prostate-Specific Antigen Response to Infusional 5-Flourouracil in Castrate-Resistant Prostate Cancer

Charlotte Manogue, Elisa Ledet, A. Kumar Guddati, Brian Lewis, Oliver Sartor

Research output: Contribution to journalArticle


Prostate cancer that has progressed after androgen deprivation, abiraterone, and taxane therapy is challenging to treat successfully. Herein we report a dramatic response to continuous-infusion 5-fluorouracil (5-FU) at a dose of 200 mg/m 2 in a patient with rapidly progressive, heavily pretreated, metastatic castrate-resistant prostate cancer. Baseline prostate-specific antigen values declined from 1,890 ng/mL to <1 ng/mL after 5-FU therapy. We hypothesized that prostate-specific membrane antigen overexpression may result in cancer cells uniquely susceptible to antifolate therapies.

Original languageEnglish (US)
Pages (from-to)383-385
Number of pages3
Issue number3
StatePublished - Mar 2018
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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