Extreme shear rate dependence of leukocyte rolling in CD18-/-E-selectin/-double mutant mice

Brad Forlow; Dan Bullard; Arthur Beaudet; Klaus Ley

Extreme shear rate dependence of leukocyte rolling in CD18-/-E-selectin/-double mutant mice

Brad Forlow, Dan Bullard, Arthur Beaudet, Klaus Ley

Research output: Contribution to journal › Conference article › peer-review

Abstract

A study was carried out to examine the impact of shear rate on slow leukocyte rolling and subsequent adhesion in C57BL/6 mice lacking CD18 integrins (CD18-/-), and/or E-selectin (CD62E-/-) using a TNFα-induced model of inflammation of the mouse cremaster muscle. In general, the combined deficiency of CD18 and E-selectin produced the most severe reduction of neutrophil recruitment in any mouse model described so far.

Original language	English (US)
Pages (from-to)	S-91
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Externally published	Yes
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

ASJC Scopus subject areas

Biomedical Engineering

Cite this

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title = "Extreme shear rate dependence of leukocyte rolling in CD18-/-E-selectin/-double mutant mice",

abstract = "A study was carried out to examine the impact of shear rate on slow leukocyte rolling and subsequent adhesion in C57BL/6 mice lacking CD18 integrins (CD18-/-), and/or E-selectin (CD62E-/-) using a TNFα-induced model of inflammation of the mouse cremaster muscle. In general, the combined deficiency of CD18 and E-selectin produced the most severe reduction of neutrophil recruitment in any mouse model described so far.",

author = "Brad Forlow and Dan Bullard and Arthur Beaudet and Klaus Ley",

year = "2000",

language = "English (US)",

volume = "28",

pages = "S--91",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

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number = "SUPPL. 1",

note = "2000 Annual Fall Meeting of the Biomedical Engineering Society ; Conference date: 12-10-2000 Through 14-10-2000",

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AU - Forlow, Brad

AU - Bullard, Dan

AU - Beaudet, Arthur

AU - Ley, Klaus

PY - 2000

Y1 - 2000

N2 - A study was carried out to examine the impact of shear rate on slow leukocyte rolling and subsequent adhesion in C57BL/6 mice lacking CD18 integrins (CD18-/-), and/or E-selectin (CD62E-/-) using a TNFα-induced model of inflammation of the mouse cremaster muscle. In general, the combined deficiency of CD18 and E-selectin produced the most severe reduction of neutrophil recruitment in any mouse model described so far.

AB - A study was carried out to examine the impact of shear rate on slow leukocyte rolling and subsequent adhesion in C57BL/6 mice lacking CD18 integrins (CD18-/-), and/or E-selectin (CD62E-/-) using a TNFα-induced model of inflammation of the mouse cremaster muscle. In general, the combined deficiency of CD18 and E-selectin produced the most severe reduction of neutrophil recruitment in any mouse model described so far.

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M3 - Conference article

AN - SCOPUS:0034510958

SN - 0090-6964

VL - 28

SP - S-91

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - SUPPL. 1

T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society

Y2 - 12 October 2000 through 14 October 2000

ER -

Extreme shear rate dependence of leukocyte rolling in CD18-/-E-selectin/-double mutant mice

Abstract

ASJC Scopus subject areas

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