FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid

Akira Murakami; Yoshimasa Nakamura; Koichi Koshimizu; Daisuke Takahashi; Kazuhiro Matsumoto; Kazuma Hagihara; Hisaji Taniguchi; Eisaku Nomura; Asao Hosoda; Takuo Tsuno; Yuko Maruta; Ha Won Kim; Kyuichi Kawabata; Hajime Ohigashi

doi:10.1016/S0304-3835(01)00858-8

FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid

Akira Murakami, Yoshimasa Nakamura, Koichi Koshimizu, Daisuke Takahashi, Kazuhiro Matsumoto, Kazuma Hagihara, Hisaji Taniguchi, Eisaku Nomura, Asao Hosoda, Takuo Tsuno, Yuko Maruta, Ha Won Kim, Kyuichi Kawabata, Hajime Ohigashi

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.

Original language	English (US)
Pages (from-to)	121-129
Number of pages	9
Journal	Cancer Letters
Volume	180
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(01)00858-8
State	Published - Jun 28 2002
Externally published	Yes

Keywords

Cyclooxygenase-2
I-κB
Inducible nitric oxide synthase
Oxidative stress
Tumor necrosis factor-α

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(01)00858-8

Cite this

Murakami, A., Nakamura, Y., Koshimizu, K., Takahashi, D., Matsumoto, K., Hagihara, K., Taniguchi, H., Nomura, E., Hosoda, A., Tsuno, T., Maruta, Y., Kim, H. W., Kawabata, K., & Ohigashi, H. (2002). FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid. Cancer Letters, 180(2), 121-129. https://doi.org/10.1016/S0304-3835(01)00858-8

Murakami, A, Nakamura, Y, Koshimizu, K, Takahashi, D, Matsumoto, K, Hagihara, K, Taniguchi, H, Nomura, E, Hosoda, A, Tsuno, T, Maruta, Y, Kim, HW, Kawabata, K & Ohigashi, H 2002, 'FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid', Cancer Letters, vol. 180, no. 2, pp. 121-129. https://doi.org/10.1016/S0304-3835(01)00858-8

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title = "FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid",

abstract = "In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.",

keywords = "Cyclooxygenase-2, I-κB, Inducible nitric oxide synthase, Oxidative stress, Tumor necrosis factor-α",

author = "Akira Murakami and Yoshimasa Nakamura and Koichi Koshimizu and Daisuke Takahashi and Kazuhiro Matsumoto and Kazuma Hagihara and Hisaji Taniguchi and Eisaku Nomura and Asao Hosoda and Takuo Tsuno and Yuko Maruta and Kim, {Ha Won} and Kyuichi Kawabata and Hajime Ohigashi",

note = "Funding Information: This research was performed with the support of Special Coordination Funds for Promoting Science and Technology (Leading Research Utilizing the Potential of Regional Science and Technology) from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government.",

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doi = "10.1016/S0304-3835(01)00858-8",

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volume = "180",

pages = "121--129",

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T1 - FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion

T2 - Comparison with ferulic acid

AU - Murakami, Akira

AU - Nakamura, Yoshimasa

AU - Koshimizu, Koichi

AU - Takahashi, Daisuke

AU - Matsumoto, Kazuhiro

AU - Hagihara, Kazuma

AU - Taniguchi, Hisaji

AU - Nomura, Eisaku

AU - Hosoda, Asao

AU - Tsuno, Takuo

AU - Maruta, Yuko

AU - Kim, Ha Won

AU - Kawabata, Kyuichi

AU - Ohigashi, Hajime

N1 - Funding Information: This research was performed with the support of Special Coordination Funds for Promoting Science and Technology (Leading Research Utilizing the Potential of Regional Science and Technology) from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government.

PY - 2002/6/28

Y1 - 2002/6/28

N2 - In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.

AB - In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.

KW - Cyclooxygenase-2

KW - I-κB

KW - Inducible nitric oxide synthase

KW - Oxidative stress

KW - Tumor necrosis factor-α

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ER -

FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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