FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid

Akira Murakami, Yoshimasa Nakamura, Koichi Koshimizu, Daisuke Takahashi, Kazuhiro Matsumoto, Kazuma Hagihara, Hisaji Taniguchi, Eisaku Nomura, Asao Hosoda, Takuo Tsuno, Yuko Maruta, Ha Won Kim, Kyuichi Kawabata, Hajime Ohigashi

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalCancer Letters
Volume180
Issue number2
DOIs
StatePublished - Jun 28 2002
Externally publishedYes

Keywords

  • Cyclooxygenase-2
  • I-κB
  • Inducible nitric oxide synthase
  • Oxidative stress
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid'. Together they form a unique fingerprint.

  • Cite this

    Murakami, A., Nakamura, Y., Koshimizu, K., Takahashi, D., Matsumoto, K., Hagihara, K., Taniguchi, H., Nomura, E., Hosoda, A., Tsuno, T., Maruta, Y., Kim, H. W., Kawabata, K., & Ohigashi, H. (2002). FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid. Cancer Letters, 180(2), 121-129. https://doi.org/10.1016/S0304-3835(01)00858-8