Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing

Donald C. Aduba, Seon Sook An, Gretchen S. Selders, Juan Wang, W. Andrew Yeudall, Gary L. Bowlin, Todd Kitten, Hu Yang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.

Original languageEnglish (US)
Pages (from-to)2456-2465
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume104
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Kirby-Bauer disk diffusion susceptibility test
  • arabinoxylan
  • polysaccharide
  • silver dressing
  • wound healing

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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