Factors affecting outcome following treatment of patients with cavernous sinus meningiomas

Michael E. Sughrue, Martin J. Rutkowski, Derick Aranda, Igor J. Barani, Michael W. McDermott, Andrew T. Parsa

Research output: Contribution to journalArticle

Abstract

Object. Although there is a considerable volume of literature available on the treatment of patients with cavernous sinus meningiomas (CSMs), most of the data regarding tumor control and survival come from case studies or single-institution series. The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors. Methods. The authors systematically analyzed the published literature and found more than 3000 patients treated for CSMs. Separate meta-analyses were performed to calculate pooled rates of recurrence and cranial neuropathy after 1) gross-total resection, 2) subtotal resection without adjuvant postoperative radiotherapy or radiosurgery, and 3) stereotactic radiosurgery (SRS) alone. Results were expressed as pooled proportions, and random-effects models were used to incorporate any heterogeneity present to generate a pooled proportion. Individual studies were weighted using the inverse variance method, and 95% CIs for each group were calculated from the pooled proportions. Results. A total of 2065 nonduplicated patients treated for CSM met inclusion criteria for the analysis. Comparisons of the 95% CIs for recurrence of these 3 cohorts revealed that SRS-treated patients experienced improved rates of recurrence (3.2% [95% CI 1.9-4.5%]) compared with either gross-total resection (11.8% [95% CI 7.4-16.1%]) or subtotal resection alone (11.1% [95% CI 6.6-15.7%]) (p < 0.01). The authors found that the pooled mixed-effects rate of cranial neuropathy was markedly higher in patients undergoing resection (59.6% [95% CI 50.3-67.5%]) than for those undergoing SRS alone (25.7% [95% CI 11.5-38.9%]) (p < 0.05). Conclusions. Radiosurgery provided improved rates of tumor control compared with surgery alone, regardless of the subjective extent of resection.

Original languageEnglish (US)
Pages (from-to)1087-1092
Number of pages6
JournalJournal of neurosurgery
Volume113
Issue number5
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

Cavernous Sinus
Meningioma
Radiosurgery
Cranial Nerve Diseases
Recurrence
Meta-Analysis
Neoplasms
Adjuvant Radiotherapy
Survival Rate
Survival

Keywords

  • Cavernous sinus meningioma
  • Meningioma
  • Radiosurgery
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Sughrue, M. E., Rutkowski, M. J., Aranda, D., Barani, I. J., McDermott, M. W., & Parsa, A. T. (2010). Factors affecting outcome following treatment of patients with cavernous sinus meningiomas. Journal of neurosurgery, 113(5), 1087-1092. https://doi.org/10.3171/2010.3.JNS091807

Factors affecting outcome following treatment of patients with cavernous sinus meningiomas. / Sughrue, Michael E.; Rutkowski, Martin J.; Aranda, Derick; Barani, Igor J.; McDermott, Michael W.; Parsa, Andrew T.

In: Journal of neurosurgery, Vol. 113, No. 5, 01.11.2010, p. 1087-1092.

Research output: Contribution to journalArticle

Sughrue, ME, Rutkowski, MJ, Aranda, D, Barani, IJ, McDermott, MW & Parsa, AT 2010, 'Factors affecting outcome following treatment of patients with cavernous sinus meningiomas', Journal of neurosurgery, vol. 113, no. 5, pp. 1087-1092. https://doi.org/10.3171/2010.3.JNS091807
Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, McDermott MW, Parsa AT. Factors affecting outcome following treatment of patients with cavernous sinus meningiomas. Journal of neurosurgery. 2010 Nov 1;113(5):1087-1092. https://doi.org/10.3171/2010.3.JNS091807
Sughrue, Michael E. ; Rutkowski, Martin J. ; Aranda, Derick ; Barani, Igor J. ; McDermott, Michael W. ; Parsa, Andrew T. / Factors affecting outcome following treatment of patients with cavernous sinus meningiomas. In: Journal of neurosurgery. 2010 ; Vol. 113, No. 5. pp. 1087-1092.
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abstract = "Object. Although there is a considerable volume of literature available on the treatment of patients with cavernous sinus meningiomas (CSMs), most of the data regarding tumor control and survival come from case studies or single-institution series. The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors. Methods. The authors systematically analyzed the published literature and found more than 3000 patients treated for CSMs. Separate meta-analyses were performed to calculate pooled rates of recurrence and cranial neuropathy after 1) gross-total resection, 2) subtotal resection without adjuvant postoperative radiotherapy or radiosurgery, and 3) stereotactic radiosurgery (SRS) alone. Results were expressed as pooled proportions, and random-effects models were used to incorporate any heterogeneity present to generate a pooled proportion. Individual studies were weighted using the inverse variance method, and 95{\%} CIs for each group were calculated from the pooled proportions. Results. A total of 2065 nonduplicated patients treated for CSM met inclusion criteria for the analysis. Comparisons of the 95{\%} CIs for recurrence of these 3 cohorts revealed that SRS-treated patients experienced improved rates of recurrence (3.2{\%} [95{\%} CI 1.9-4.5{\%}]) compared with either gross-total resection (11.8{\%} [95{\%} CI 7.4-16.1{\%}]) or subtotal resection alone (11.1{\%} [95{\%} CI 6.6-15.7{\%}]) (p < 0.01). The authors found that the pooled mixed-effects rate of cranial neuropathy was markedly higher in patients undergoing resection (59.6{\%} [95{\%} CI 50.3-67.5{\%}]) than for those undergoing SRS alone (25.7{\%} [95{\%} CI 11.5-38.9{\%}]) (p < 0.05). Conclusions. Radiosurgery provided improved rates of tumor control compared with surgery alone, regardless of the subjective extent of resection.",
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AU - McDermott, Michael W.

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N2 - Object. Although there is a considerable volume of literature available on the treatment of patients with cavernous sinus meningiomas (CSMs), most of the data regarding tumor control and survival come from case studies or single-institution series. The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors. Methods. The authors systematically analyzed the published literature and found more than 3000 patients treated for CSMs. Separate meta-analyses were performed to calculate pooled rates of recurrence and cranial neuropathy after 1) gross-total resection, 2) subtotal resection without adjuvant postoperative radiotherapy or radiosurgery, and 3) stereotactic radiosurgery (SRS) alone. Results were expressed as pooled proportions, and random-effects models were used to incorporate any heterogeneity present to generate a pooled proportion. Individual studies were weighted using the inverse variance method, and 95% CIs for each group were calculated from the pooled proportions. Results. A total of 2065 nonduplicated patients treated for CSM met inclusion criteria for the analysis. Comparisons of the 95% CIs for recurrence of these 3 cohorts revealed that SRS-treated patients experienced improved rates of recurrence (3.2% [95% CI 1.9-4.5%]) compared with either gross-total resection (11.8% [95% CI 7.4-16.1%]) or subtotal resection alone (11.1% [95% CI 6.6-15.7%]) (p < 0.01). The authors found that the pooled mixed-effects rate of cranial neuropathy was markedly higher in patients undergoing resection (59.6% [95% CI 50.3-67.5%]) than for those undergoing SRS alone (25.7% [95% CI 11.5-38.9%]) (p < 0.05). Conclusions. Radiosurgery provided improved rates of tumor control compared with surgery alone, regardless of the subjective extent of resection.

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