Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma

Significance of intensive neoadjuvant chemotherapy and radiation break

Luying Xu, Jianji Pan, Junxin Wu, Caizhu Pan, Yu Zhang, Shaojun Lin, Ling Yang, Chuanben Chen, Chun Zhang, Wei Zheng, Senan Lin, Xiaolei Ni, Feng Ming (Spring) Kong

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background and purpose: To exam factors associated with overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). Materials and methods: This study is a retrospective study of a total of 1706 consecutive NPC patients from a single institution between January 1995 and December 1998. One thousand eighty-one patients were treated with radiotherapy (RT) alone and 625 with an intensive course of neoadjuvant chemotherapy followed by RT. Patient, tumor and treatment factors were analyzed for their significance on 5-year overall survival (OS). Results: Younger age, female gender, absence of anemia pre-RT, early tumor stage, interruption of RT, and neoadjuvant chemotherapy were significantly associated with survival under multivariate analysis (all P < 0.05). The 5-year OS rates were 100%, 75.9% (95%CI 71.6-80.2%), 66.5% (95%CI 62.8-70.2%), and 49.3% (95%CI 45.0-53.6%) for stage I, II, III, and IV (P < 0.05); 68.9% (95%CI 66.2-71.5%) and 63.7% (95%CI 61.5-65.8%), for patients treated with or without neoadjuvant chemotherapy (P = 0.0051), and 51.7% (95%CI 45.0-58.4%) and 69.5% (95%CI 67.2-71.7%) for patients with or without treatment break (P < 0.0001), respectively. Conclusion: Intensive neoadjuvant chemotherapy and absence of radiation break seem to be favorable factors associated with long-term survival in patients with NPC.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
JournalRadiotherapy and Oncology
Volume96
Issue number1
DOIs
StatePublished - Jul 1 2010

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Radiation
Drug Therapy
Survival
Radiotherapy
Nasopharyngeal carcinoma
Anemia
Neoplasms
Multivariate Analysis
Survival Rate
Retrospective Studies
Therapeutics

Keywords

  • Nasopharyngeal cancer
  • Neoadjuvant chemotherapy
  • Radiation break

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma : Significance of intensive neoadjuvant chemotherapy and radiation break. / Xu, Luying; Pan, Jianji; Wu, Junxin; Pan, Caizhu; Zhang, Yu; Lin, Shaojun; Yang, Ling; Chen, Chuanben; Zhang, Chun; Zheng, Wei; Lin, Senan; Ni, Xiaolei; (Spring) Kong, Feng Ming.

In: Radiotherapy and Oncology, Vol. 96, No. 1, 01.07.2010, p. 94-99.

Research output: Contribution to journalArticle

Xu, L, Pan, J, Wu, J, Pan, C, Zhang, Y, Lin, S, Yang, L, Chen, C, Zhang, C, Zheng, W, Lin, S, Ni, X & (Spring) Kong, FM 2010, 'Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: Significance of intensive neoadjuvant chemotherapy and radiation break', Radiotherapy and Oncology, vol. 96, no. 1, pp. 94-99. https://doi.org/10.1016/j.radonc.2010.04.006
Xu, Luying ; Pan, Jianji ; Wu, Junxin ; Pan, Caizhu ; Zhang, Yu ; Lin, Shaojun ; Yang, Ling ; Chen, Chuanben ; Zhang, Chun ; Zheng, Wei ; Lin, Senan ; Ni, Xiaolei ; (Spring) Kong, Feng Ming. / Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma : Significance of intensive neoadjuvant chemotherapy and radiation break. In: Radiotherapy and Oncology. 2010 ; Vol. 96, No. 1. pp. 94-99.
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T1 - Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma

T2 - Significance of intensive neoadjuvant chemotherapy and radiation break

AU - Xu, Luying

AU - Pan, Jianji

AU - Wu, Junxin

AU - Pan, Caizhu

AU - Zhang, Yu

AU - Lin, Shaojun

AU - Yang, Ling

AU - Chen, Chuanben

AU - Zhang, Chun

AU - Zheng, Wei

AU - Lin, Senan

AU - Ni, Xiaolei

AU - (Spring) Kong, Feng Ming

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Background and purpose: To exam factors associated with overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). Materials and methods: This study is a retrospective study of a total of 1706 consecutive NPC patients from a single institution between January 1995 and December 1998. One thousand eighty-one patients were treated with radiotherapy (RT) alone and 625 with an intensive course of neoadjuvant chemotherapy followed by RT. Patient, tumor and treatment factors were analyzed for their significance on 5-year overall survival (OS). Results: Younger age, female gender, absence of anemia pre-RT, early tumor stage, interruption of RT, and neoadjuvant chemotherapy were significantly associated with survival under multivariate analysis (all P < 0.05). The 5-year OS rates were 100%, 75.9% (95%CI 71.6-80.2%), 66.5% (95%CI 62.8-70.2%), and 49.3% (95%CI 45.0-53.6%) for stage I, II, III, and IV (P < 0.05); 68.9% (95%CI 66.2-71.5%) and 63.7% (95%CI 61.5-65.8%), for patients treated with or without neoadjuvant chemotherapy (P = 0.0051), and 51.7% (95%CI 45.0-58.4%) and 69.5% (95%CI 67.2-71.7%) for patients with or without treatment break (P < 0.0001), respectively. Conclusion: Intensive neoadjuvant chemotherapy and absence of radiation break seem to be favorable factors associated with long-term survival in patients with NPC.

AB - Background and purpose: To exam factors associated with overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). Materials and methods: This study is a retrospective study of a total of 1706 consecutive NPC patients from a single institution between January 1995 and December 1998. One thousand eighty-one patients were treated with radiotherapy (RT) alone and 625 with an intensive course of neoadjuvant chemotherapy followed by RT. Patient, tumor and treatment factors were analyzed for their significance on 5-year overall survival (OS). Results: Younger age, female gender, absence of anemia pre-RT, early tumor stage, interruption of RT, and neoadjuvant chemotherapy were significantly associated with survival under multivariate analysis (all P < 0.05). The 5-year OS rates were 100%, 75.9% (95%CI 71.6-80.2%), 66.5% (95%CI 62.8-70.2%), and 49.3% (95%CI 45.0-53.6%) for stage I, II, III, and IV (P < 0.05); 68.9% (95%CI 66.2-71.5%) and 63.7% (95%CI 61.5-65.8%), for patients treated with or without neoadjuvant chemotherapy (P = 0.0051), and 51.7% (95%CI 45.0-58.4%) and 69.5% (95%CI 67.2-71.7%) for patients with or without treatment break (P < 0.0001), respectively. Conclusion: Intensive neoadjuvant chemotherapy and absence of radiation break seem to be favorable factors associated with long-term survival in patients with NPC.

KW - Nasopharyngeal cancer

KW - Neoadjuvant chemotherapy

KW - Radiation break

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