Abstract
Studies of airway responsiveness (AR) have typically used similar dose schedules of methacholine for adults and children despite large ranges in subject size. Reported declines in AR with increasing age in children could be due to maturational changes or to proportionately smaller doses of methacholine in taller (older) children. Other investigators have related both height and various measures of lung function to AR. We examined data related to AR in 471 children, aged 6 to 8 yr, from a birth cohort. Each child underwent spirometry followed by sequential challenge with five doses of methacholine, ranging from 0.025 to 25 mg/ml, given with a dosimeter. Continuous slope and end FEV1-change indexes of responsiveness were computed. Using stepwise regression modeling, we found no significant association between AR and either height or age after entering a variable reflecting asthma or wheezing. In contrast, we found that baseline measures of FVC, FEV1/FVC, and FEF25-75(%) were significantly related to AR after controlling for other variables (p = 0.001). However, when all three of the latter measures were added to models, FEF25-75(%) was most closely related to AR. We conclude that after control for other variables, FEF25- 75(%) and FVC, but not height, are significantly related to methacholine responsiveness in children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1578-1583 |
| Number of pages | 6 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 161 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2000 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
Cite this
Factors related to methacholine airway responsiveness in children. / Ownby, Dennis Randall; Peterson, Edward L.; Johnson, Christine C.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 161, No. 5, 01.01.2000, p. 1578-1583.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors related to methacholine airway responsiveness in children
AU - Ownby, Dennis Randall
AU - Peterson, Edward L.
AU - Johnson, Christine C.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Studies of airway responsiveness (AR) have typically used similar dose schedules of methacholine for adults and children despite large ranges in subject size. Reported declines in AR with increasing age in children could be due to maturational changes or to proportionately smaller doses of methacholine in taller (older) children. Other investigators have related both height and various measures of lung function to AR. We examined data related to AR in 471 children, aged 6 to 8 yr, from a birth cohort. Each child underwent spirometry followed by sequential challenge with five doses of methacholine, ranging from 0.025 to 25 mg/ml, given with a dosimeter. Continuous slope and end FEV1-change indexes of responsiveness were computed. Using stepwise regression modeling, we found no significant association between AR and either height or age after entering a variable reflecting asthma or wheezing. In contrast, we found that baseline measures of FVC, FEV1/FVC, and FEF25-75(%) were significantly related to AR after controlling for other variables (p = 0.001). However, when all three of the latter measures were added to models, FEF25-75(%) was most closely related to AR. We conclude that after control for other variables, FEF25- 75(%) and FVC, but not height, are significantly related to methacholine responsiveness in children.
AB - Studies of airway responsiveness (AR) have typically used similar dose schedules of methacholine for adults and children despite large ranges in subject size. Reported declines in AR with increasing age in children could be due to maturational changes or to proportionately smaller doses of methacholine in taller (older) children. Other investigators have related both height and various measures of lung function to AR. We examined data related to AR in 471 children, aged 6 to 8 yr, from a birth cohort. Each child underwent spirometry followed by sequential challenge with five doses of methacholine, ranging from 0.025 to 25 mg/ml, given with a dosimeter. Continuous slope and end FEV1-change indexes of responsiveness were computed. Using stepwise regression modeling, we found no significant association between AR and either height or age after entering a variable reflecting asthma or wheezing. In contrast, we found that baseline measures of FVC, FEV1/FVC, and FEF25-75(%) were significantly related to AR after controlling for other variables (p = 0.001). However, when all three of the latter measures were added to models, FEF25-75(%) was most closely related to AR. We conclude that after control for other variables, FEF25- 75(%) and FVC, but not height, are significantly related to methacholine responsiveness in children.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034109724&partnerID=8YFLogxK
U2 - 10.1164/ajrccm.161.5.9812156
DO - 10.1164/ajrccm.161.5.9812156
M3 - Article
C2 - 10806158
AN - SCOPUS:0034109724
VL - 161
SP - 1578
EP - 1583
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 5
ER -