Failure of a glass ionomer to remineralize apatite-depleted dentin

Y. K. Kim, C. K.Y. Yiu, J. R. Kim, L. Gu, S. K. Kim, R. N. Weller, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IX GP, and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1-4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalJournal of Dental Research
Volume89
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Apatites
Dentin
Glass Ionomer Cements
Strontium
carbopol 940
Transmission Electron Microscopy
Biomimetics
Acids
Body Fluids
Minerals
glass ionomer
Ions

Keywords

  • Apatite
  • Demineralized dentin
  • Glass-ionomer cement
  • Ion diffusion.
  • Remineralization

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Kim, Y. K., Yiu, C. K. Y., Kim, J. R., Gu, L., Kim, S. K., Weller, R. N., ... Tay, F. C. M. (2010). Failure of a glass ionomer to remineralize apatite-depleted dentin. Journal of Dental Research, 89(3), 230-235. https://doi.org/10.1177/0022034509357172

Failure of a glass ionomer to remineralize apatite-depleted dentin. / Kim, Y. K.; Yiu, C. K.Y.; Kim, J. R.; Gu, L.; Kim, S. K.; Weller, R. N.; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Journal of Dental Research, Vol. 89, No. 3, 01.03.2010, p. 230-235.

Research output: Contribution to journalArticle

Kim, YK, Yiu, CKY, Kim, JR, Gu, L, Kim, SK, Weller, RN, Pashley, DH & Tay, FCM 2010, 'Failure of a glass ionomer to remineralize apatite-depleted dentin', Journal of Dental Research, vol. 89, no. 3, pp. 230-235. https://doi.org/10.1177/0022034509357172
Kim, Y. K. ; Yiu, C. K.Y. ; Kim, J. R. ; Gu, L. ; Kim, S. K. ; Weller, R. N. ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Failure of a glass ionomer to remineralize apatite-depleted dentin. In: Journal of Dental Research. 2010 ; Vol. 89, No. 3. pp. 230-235.
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