TY - JOUR
T1 - Failure of host axons to regenerate through a once successful but later rejected long nerve allograft
AU - Zalewski, Andrew A.
AU - Silvers, Willys K.
AU - Gulati, Adarsh K.
PY - 1982/8/20
Y1 - 1982/8/20
N2 - Host axons will regenerate through a long nerve allograft in an immunologically tolerant rat. However, if tolerance is abolished, rejection occurs and allogeneic cells (e.g., Schwann, vascular, perineurial, etc.) as well as regenerated host axons disappear from the allograft. Because following tolerance abolition host axons begin to regenerate into the connective tissue remnants of the rejected nerve allografts, the extent of this renewed axonal growth was investigated. It was found that in a tolerance‐abolished rat, host axons only regrew into the proximal 1 cm of a 4‐cm allograft which in a fully tolerant recipient would have had numerous allogeneic Schwann cell‐myelinated axons throughout its length. It is concluded that viable allogeneic cells (i.e., Schwann, fibroblast, and vascular) together with their connective tissue matrix provide the best way to aid host nerve fiber regeneration through a long nerve allograft.
AB - Host axons will regenerate through a long nerve allograft in an immunologically tolerant rat. However, if tolerance is abolished, rejection occurs and allogeneic cells (e.g., Schwann, vascular, perineurial, etc.) as well as regenerated host axons disappear from the allograft. Because following tolerance abolition host axons begin to regenerate into the connective tissue remnants of the rejected nerve allografts, the extent of this renewed axonal growth was investigated. It was found that in a tolerance‐abolished rat, host axons only regrew into the proximal 1 cm of a 4‐cm allograft which in a fully tolerant recipient would have had numerous allogeneic Schwann cell‐myelinated axons throughout its length. It is concluded that viable allogeneic cells (i.e., Schwann, fibroblast, and vascular) together with their connective tissue matrix provide the best way to aid host nerve fiber regeneration through a long nerve allograft.
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U2 - 10.1002/cne.902090404
DO - 10.1002/cne.902090404
M3 - Article
C2 - 6982286
AN - SCOPUS:0019905199
SN - 0021-9967
VL - 209
SP - 347
EP - 351
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
IS - 4
ER -