FAK interaction with MBD2: A link from cell adhesion to nuclear chromatin remodeling?

Lin Mei, Wencheng Xiong

Research output: Contribution to journalComment/debate

13 Citations (Scopus)

Abstract

Cell adhesion, migration, proliferation, and differentiation are tightly linked and coordinated cellular processes. Cell adhesion dependent gene expression is believed to contribute to such coordination. Focal adhesion kinase (FAK) and its related protein, PYK2 (proline rich tyrosine kinase 2), are a major family of cell adhesion activated tyrosine kinases that play important roles in these cellular processes. Whereas FAK or PYK2 is known to be a scaffold protein, recruiting many cytoplasmic proteins into the focal adhesion complex and regulating focal adhesion turnover and cell migration, how FAK or PYK2 links to the nuclei and regulates gene expression remain largely unclear. We recently report a new signaling of FAK in regulating heterochromatin remodeling by its interaction with MBD2 (Methyl CpG binding domain protein 2), which may underlie FAK regulation of myogenin expression and muscle differentiation. Two insights have been obtained through the analysis of FAK-MBD2 interaction. The interaction appears to be sufficient, but not necessary, for FAK translocation into or maintaining in the nucleus. The nuclear FAK-MBD2 complexes cause altered heterochromatin organization and decreased MBD2 association with HDAC1 (histone deacetylase complex 1) and methyl CpG site in the myogenin promoter, thus, inducing myogenin expression. These results demonstrate a new mechanism underlying FAK regulation of gene expression, and suggest a potential link between cell adhesion and cell differentiation.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalCell Adhesion and Migration
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Focal Adhesion Protein-Tyrosine Kinases
Chromatin Assembly and Disassembly
Cell Adhesion
Myogenin
Focal Adhesions
Heterochromatin
Cell Movement
Focal Adhesion Kinase 2
Histone Deacetylase 1
Gene Expression
MBD2 protein
Proteins
Histone Deacetylases
Gene Expression Regulation
Protein-Tyrosine Kinases
Cell Differentiation
Muscles

Keywords

  • FAK
  • MBD2
  • Muscle differentiation
  • Myogenin
  • PYK2

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

FAK interaction with MBD2 : A link from cell adhesion to nuclear chromatin remodeling? / Mei, Lin; Xiong, Wencheng.

In: Cell Adhesion and Migration, Vol. 4, No. 1, 01.01.2010, p. 77-80.

Research output: Contribution to journalComment/debate

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