Familial clustering of pulmonary nontuberculous mycobacterial disease

Rhonda Elizabeth Colombo, Suvimol C. Hill, Reginald J. Claypool, Steven M. Holland, Kenneth N. Olivier

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Nontuberculous mycobacteria (NTM) are environmental organisms associated with pulmonary disease without person-to-person transmission. Although genetic causes of disseminated NTM infection are well characterized, genetic causes for most human susceptibility to pulmonary NTM infection have not been determined. Methods: Family histories for relevant disease characteristics were obtained as part of an ongoing natural history study. Six families were identified in which at least two blood relatives had pulmonary NTM. A systematic review of medical records extracted data relevant to pulmonary infection and baseline demographics. Data were reconfirmed by telephone interviews. Results: Familial clustering of pulmonary NTM was proven in six families. Four of the families were white, and the majority of affected individuals were women. The average age at diagnosis was 56.4 ± 10.7 years, the average height was 167.5 ± 8.7 cm, and the mean BMI was 22.0 ± 2.98 kg/m2. Scoliosis was present in 31%. Five of 12 patients had cystic fibrosis transmembrane conductance regulator gene variations, but none had classic cystic fibrosis. Infections were caused by both slow and rapid growing mycobacteria, including Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium kansasii, Mycobacterium abscessus, and Mycobacterium massiliense. Family members were typically infected with different species of NTM. Conclusion: We identified six familial clusters of pulmonary NTM infection, suggesting that there are genetic factors contributing to host susceptibility to pulmonary infection with NTM among some individuals with nodular bronchiectatic disease.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalChest
Volume137
Issue number3
DOIs
StatePublished - Mar 1 2010

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Nontuberculous Mycobacterium Infections
Cluster Analysis
Nontuberculous Mycobacteria
Lung
Mycobacterium
Mycobacterium avium Complex
Mycobacterium kansasii
Cystic Fibrosis Transmembrane Conductance Regulator
Scoliosis
Regulator Genes
Infection
Natural History
Cystic Fibrosis
Lung Diseases
Medical Records
Demography
Interviews

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Colombo, R. E., Hill, S. C., Claypool, R. J., Holland, S. M., & Olivier, K. N. (2010). Familial clustering of pulmonary nontuberculous mycobacterial disease. Chest, 137(3), 629-634. https://doi.org/10.1378/chest.09-1173

Familial clustering of pulmonary nontuberculous mycobacterial disease. / Colombo, Rhonda Elizabeth; Hill, Suvimol C.; Claypool, Reginald J.; Holland, Steven M.; Olivier, Kenneth N.

In: Chest, Vol. 137, No. 3, 01.03.2010, p. 629-634.

Research output: Contribution to journalArticle

Colombo, RE, Hill, SC, Claypool, RJ, Holland, SM & Olivier, KN 2010, 'Familial clustering of pulmonary nontuberculous mycobacterial disease', Chest, vol. 137, no. 3, pp. 629-634. https://doi.org/10.1378/chest.09-1173
Colombo RE, Hill SC, Claypool RJ, Holland SM, Olivier KN. Familial clustering of pulmonary nontuberculous mycobacterial disease. Chest. 2010 Mar 1;137(3):629-634. https://doi.org/10.1378/chest.09-1173
Colombo, Rhonda Elizabeth ; Hill, Suvimol C. ; Claypool, Reginald J. ; Holland, Steven M. ; Olivier, Kenneth N. / Familial clustering of pulmonary nontuberculous mycobacterial disease. In: Chest. 2010 ; Vol. 137, No. 3. pp. 629-634.
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