Family History and the Risk of Breast Cancer

Cancer and Steroid Hormone Study

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

To investigate whether a family history of breast cancer increases a woman's risk of developing breast cancer, we analyzed data from the Centers for Disease Control's Cancer and Steroid Hormone Study. The 4,735 cases were women 20 to 54 years old with a first diagnosis of breast cancer ascertained from eight population-based cancer registries; the 4,688 controls were women selected at random from the general population of these eight areas. Compared with women without a family history of breast cancer, women who had an affected first-degree relative had a relative risk of 2.3; women with an affected second-degree relative had a relative risk of 1.5; and women with both an affected mother and sister had a relative risk of 14. The risk of breast cancer for a woman was higher if her first-degree relative had unilateral rather than bilateral breast cancer or had breast cancer detected at a younger rather than older age. For women aged 20 to 39, 40 to 44, and 45 to 54 years, the estimated annual incidence of breast cancer per 100,000 women attributable to a first-degree family history of breast cancer was 51.9, 115.1, and 138.6, respectively, and that attributable to a second-degree family history of breast cancer was 12.1, 19.2, and 92.4, respectively.

Original languageEnglish (US)
Pages (from-to)1908-1913
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume253
Issue number13
DOIs
StatePublished - Apr 5 1985

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Breast Neoplasms
Centers for Disease Control and Prevention (U.S.)
Population
Registries
Siblings
Neoplasms
Steroids
Mothers
Hormones
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Family History and the Risk of Breast Cancer. / Cancer and Steroid Hormone Study.

In: JAMA: The Journal of the American Medical Association, Vol. 253, No. 13, 05.04.1985, p. 1908-1913.

Research output: Contribution to journalArticle

Cancer and Steroid Hormone Study. / Family History and the Risk of Breast Cancer. In: JAMA: The Journal of the American Medical Association. 1985 ; Vol. 253, No. 13. pp. 1908-1913.
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