Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma

Christine Cole Johnson, Dennis Randall Ownby, Suzanne L. Havstad, Edward L. Peterson

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background Dust mite allergen exposure is considered a major determinant of sensitization to these allergens during childhood and a risk factor for pediatric asthma. Objective By using a birth cohort in a setting with a substantial burden of dust mite allergen, we evaluated exposure and risk for outcomes related to allergy and asthma. Methods We collected dust from the bedrooms of 428 children born from 1987 to 1989 and measured Der f 1 and Der p 1 (μg/g dust, combined). Follow-up at 6 to 7 years of age included clinical examination, skin prick testing, specific serum IgE measurement, and methacholine challenge. Results No overall association was evident for any outcome except bronchial hyperresponsiveness (adjusted odds ratio [OR], 0.62; 95% CI, 0.38-1.00; P < .050; and OR, 0.53; CI, 0.27-1.04; P < .065 for dust mite allergen levels ≥2 μg/g and >10 μg/g, respectively). With a parental history of allergy and asthma, there was an association between a positive dust mite skin test (OR, 2.09; CI, 0.93-4.73; P < .076) and dust mite allergen level >10 μg/g. The inverse was true for children without a parental history. Dust mite exposure of >10 μg/g was associated with a decreased risk of current atopic asthma among children with a parental history (OR, 0.39; CI, 0.05-3.13; P < .376), but with increased risk if without a parental history (OR, 1.52; CI, 0.22-10.6; P < .673). Conclusion Parental history is an important independent variable in the relationship between early dust mite exposure and atopic outcomes. Increased exposure during infancy is associated with a higher risk for sensitization in the presence of a positive parental history, but is protective among children of parents without a history of atopic disease.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume114
Issue number1
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

Fingerprint

Mites
Dust
Asthma
Pediatrics
Odds Ratio
Allergens
Hypersensitivity
Methacholine Chloride
Skin Tests
Immunoglobulin E
Parents
Parturition
Skin
Serum

Keywords

  • Adjusted odds ratio
  • Allergy
  • BHR
  • Bronchial hyperresponsiveness
  • IgE
  • OR
  • asthma
  • atopy
  • bronchial hyperreactivity
  • children
  • home allergen level
  • skin testing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma. / Cole Johnson, Christine; Ownby, Dennis Randall; Havstad, Suzanne L.; Peterson, Edward L.

In: Journal of Allergy and Clinical Immunology, Vol. 114, No. 1, 01.07.2004, p. 105-110.

Research output: Contribution to journalArticle

Cole Johnson, Christine ; Ownby, Dennis Randall ; Havstad, Suzanne L. ; Peterson, Edward L. / Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma. In: Journal of Allergy and Clinical Immunology. 2004 ; Vol. 114, No. 1. pp. 105-110.
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abstract = "Background Dust mite allergen exposure is considered a major determinant of sensitization to these allergens during childhood and a risk factor for pediatric asthma. Objective By using a birth cohort in a setting with a substantial burden of dust mite allergen, we evaluated exposure and risk for outcomes related to allergy and asthma. Methods We collected dust from the bedrooms of 428 children born from 1987 to 1989 and measured Der f 1 and Der p 1 (μg/g dust, combined). Follow-up at 6 to 7 years of age included clinical examination, skin prick testing, specific serum IgE measurement, and methacholine challenge. Results No overall association was evident for any outcome except bronchial hyperresponsiveness (adjusted odds ratio [OR], 0.62; 95{\%} CI, 0.38-1.00; P < .050; and OR, 0.53; CI, 0.27-1.04; P < .065 for dust mite allergen levels ≥2 μg/g and >10 μg/g, respectively). With a parental history of allergy and asthma, there was an association between a positive dust mite skin test (OR, 2.09; CI, 0.93-4.73; P < .076) and dust mite allergen level >10 μg/g. The inverse was true for children without a parental history. Dust mite exposure of >10 μg/g was associated with a decreased risk of current atopic asthma among children with a parental history (OR, 0.39; CI, 0.05-3.13; P < .376), but with increased risk if without a parental history (OR, 1.52; CI, 0.22-10.6; P < .673). Conclusion Parental history is an important independent variable in the relationship between early dust mite exposure and atopic outcomes. Increased exposure during infancy is associated with a higher risk for sensitization in the presence of a positive parental history, but is protective among children of parents without a history of atopic disease.",
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N2 - Background Dust mite allergen exposure is considered a major determinant of sensitization to these allergens during childhood and a risk factor for pediatric asthma. Objective By using a birth cohort in a setting with a substantial burden of dust mite allergen, we evaluated exposure and risk for outcomes related to allergy and asthma. Methods We collected dust from the bedrooms of 428 children born from 1987 to 1989 and measured Der f 1 and Der p 1 (μg/g dust, combined). Follow-up at 6 to 7 years of age included clinical examination, skin prick testing, specific serum IgE measurement, and methacholine challenge. Results No overall association was evident for any outcome except bronchial hyperresponsiveness (adjusted odds ratio [OR], 0.62; 95% CI, 0.38-1.00; P < .050; and OR, 0.53; CI, 0.27-1.04; P < .065 for dust mite allergen levels ≥2 μg/g and >10 μg/g, respectively). With a parental history of allergy and asthma, there was an association between a positive dust mite skin test (OR, 2.09; CI, 0.93-4.73; P < .076) and dust mite allergen level >10 μg/g. The inverse was true for children without a parental history. Dust mite exposure of >10 μg/g was associated with a decreased risk of current atopic asthma among children with a parental history (OR, 0.39; CI, 0.05-3.13; P < .376), but with increased risk if without a parental history (OR, 1.52; CI, 0.22-10.6; P < .673). Conclusion Parental history is an important independent variable in the relationship between early dust mite exposure and atopic outcomes. Increased exposure during infancy is associated with a higher risk for sensitization in the presence of a positive parental history, but is protective among children of parents without a history of atopic disease.

AB - Background Dust mite allergen exposure is considered a major determinant of sensitization to these allergens during childhood and a risk factor for pediatric asthma. Objective By using a birth cohort in a setting with a substantial burden of dust mite allergen, we evaluated exposure and risk for outcomes related to allergy and asthma. Methods We collected dust from the bedrooms of 428 children born from 1987 to 1989 and measured Der f 1 and Der p 1 (μg/g dust, combined). Follow-up at 6 to 7 years of age included clinical examination, skin prick testing, specific serum IgE measurement, and methacholine challenge. Results No overall association was evident for any outcome except bronchial hyperresponsiveness (adjusted odds ratio [OR], 0.62; 95% CI, 0.38-1.00; P < .050; and OR, 0.53; CI, 0.27-1.04; P < .065 for dust mite allergen levels ≥2 μg/g and >10 μg/g, respectively). With a parental history of allergy and asthma, there was an association between a positive dust mite skin test (OR, 2.09; CI, 0.93-4.73; P < .076) and dust mite allergen level >10 μg/g. The inverse was true for children without a parental history. Dust mite exposure of >10 μg/g was associated with a decreased risk of current atopic asthma among children with a parental history (OR, 0.39; CI, 0.05-3.13; P < .376), but with increased risk if without a parental history (OR, 1.52; CI, 0.22-10.6; P < .673). Conclusion Parental history is an important independent variable in the relationship between early dust mite exposure and atopic outcomes. Increased exposure during infancy is associated with a higher risk for sensitization in the presence of a positive parental history, but is protective among children of parents without a history of atopic disease.

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