Fatal delayed transfusion reaction in a sickle cell anemia patient with Serratia marcescens sepsis

Desiree Seeyave, Ninad Desai, Scott Miller, Sreedhar P. Rao, Steve Piecuch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Patients with sickle cell anemia may require repeated red cell transfusion, putting them at risk for minor blood group alloimmunization and the development of delayed hemolytic transfusion reactions. Although Streprococcus pneumoniae is the most common cause of life-threatening infection in patients with sickle cell anemia, those who have been recently hospitalized are at risk for infection with resistant hospital-associated organisms, and blood transfusion may put the patient at risk of infection with transfusion-associated organisms such as Serratia marcescens and Yersinia enterocolitica. We recently cared for an adolescent with sickle cell anemia who presented to the emergency department with a severe, delayed hemolytic transfusion reaction and Serratia marcescens infection. The patient had been discharged from the hospital five days previously, and had been transfused and treated with antibiotics white hospitalized. In addition to demonstrating the potential severity of delayed hemolytic transfusion reactions, our case illustrates the importance of providing relatively broad-spectrum antibiotic coverage to patients with sickle cell anemia and possible infection who have recently been hospitalized.

Original languageEnglish (US)
Pages (from-to)1697-1699
Number of pages3
JournalJournal of the National Medical Association
Issue number10
StatePublished - Oct 1 2006
Externally publishedYes


  • Blood transfusion
  • Infection
  • Serratia marcescens
  • Sickle cell anemia

ASJC Scopus subject areas

  • Medicine(all)


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