Fatal group A streptococcal necrotizing myopathy

Yelena Lindenbaum, Norris Stanley Nahman, Jerry R. Mendell

Research output: Contribution to journalArticle

Abstract

A 72-year-old woman on immunosuppressive therapy for renal transplantation was admitted to the hospital for diffuse, progressive weakness that developed over several weeks. Serum creatine kinase steadily increased and she developed myoglobinuria. Blood cultures were positive for group A Streptococcus pyogenes. The muscle biopsy demonstrated a necrotizing myopathy without cellular infiltrate. Despite treatment, she evolved to multiorgan system failure and cardiovascular collapse. This is a novel presentation of group A streptococcal muscle infection with diffuse, generalized muscle weakness. It stands in striking contrast to the usual infection with this organism confined to one extremity and associated with a prolific cellular response in the muscle.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalJournal of Clinical Neuromuscular Disease
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Muscular Diseases
Muscles
Myoglobinuria
Streptococcal Infections
Streptococcus pyogenes
Muscle Weakness
Immunosuppressive Agents
Creatine Kinase
Cardiovascular System
Kidney Transplantation
Extremities
Biopsy
Therapeutics
Infection
Serum

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Fatal group A streptococcal necrotizing myopathy. / Lindenbaum, Yelena; Nahman, Norris Stanley; Mendell, Jerry R.

In: Journal of Clinical Neuromuscular Disease, Vol. 3, No. 3, 01.01.2002, p. 113-115.

Research output: Contribution to journalArticle

Lindenbaum, Yelena ; Nahman, Norris Stanley ; Mendell, Jerry R. / Fatal group A streptococcal necrotizing myopathy. In: Journal of Clinical Neuromuscular Disease. 2002 ; Vol. 3, No. 3. pp. 113-115.
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