Fatty acid oxidation affects food intake by altering hepatic energy status

Mark I. Friedman, Ruth B. Harris, Hong Ji, Israel Ramirez, Michael G. Tordoff

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Inhibition of fatty acid oxidation stimulates feeding behavior in rats. To determine whether a decrease in hepatic fatty acid oxidation triggers this behavioral response, we compared the effects of different doses of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, on food intake with those on in vivo and in vitro liver and muscle metabolism. Administration of 1 mg/kg MP selectively decreased hepatic fatty acid oxidation but did not stimulate food intake. In contrast, feeding behavior increased in rats given 5 or 10 mg/kg MP, which inhibited hepatic fatty acid oxidation to the same extent as did the low dose but in addition suppressed fatty acid oxidation in muscle and produced a marked depletion of liver glycogen. Dose-related increases in food intake tracked dose-related reductions in liver ATP content, ATP-to-ADP ratio, and phosphorylation potential. The findings suggest that a decrease in hepatic fatty acid oxidation can stimulate feeding behavior by reducing hepatic energy production.

Original languageEnglish (US)
Pages (from-to)R1046-R1053
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume276
Issue number4 45-4
StatePublished - Apr 1 1999
Externally publishedYes

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Keywords

  • Adenosine 5'-triphosphate
  • Feeding behavior
  • Liver
  • Metabolism
  • Methyl palmoxirate

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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