Fatty acid oxidation intermediates and the effect of fasting on oxidation in red and white skeletal muscle

James Edwin Carroll, Aida Villadiego, Daniel P. Morse

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In vitro oxidation of U‐[14C]glucose‐6‐phosphate, 2‐[14C]pyruvate, and 1‐[14C]pyruvate was significantly reduced in red skeletal muscle from fasting rats. Over the same time interval of fasting, 1‐[14C]palmitate oxidation remained unchanged. Pyruvate dehydrogenase activity, assayed before in vitro activation, was also reduced in red muscle. Long chain acylcarnitine and long chain acyl CoA increased over the same time period in red muscle. Changes in long chain fatty acid derivatives and pyruvate oxidation were much less dramatic in white muscle. We propose that the rise in levels of long chain fatty acid derivatives may be directly related to the inhibition of carbohydrate oxidation during fasting in red skeletal muscle.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalMuscle & Nerve
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1983

Fingerprint

Pyruvic Acid
Fasting
Skeletal Muscle
Fatty Acids
Muscles
Acyl Coenzyme A
Palmitates
Oxidoreductases
Carbohydrates
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Fatty acid oxidation intermediates and the effect of fasting on oxidation in red and white skeletal muscle. / Carroll, James Edwin; Villadiego, Aida; Morse, Daniel P.

In: Muscle & Nerve, Vol. 6, No. 5, 01.01.1983, p. 367-373.

Research output: Contribution to journalArticle

@article{d4d09d9a92714fe9ad9695fa83fefe58,
title = "Fatty acid oxidation intermediates and the effect of fasting on oxidation in red and white skeletal muscle",
abstract = "In vitro oxidation of U‐[14C]glucose‐6‐phosphate, 2‐[14C]pyruvate, and 1‐[14C]pyruvate was significantly reduced in red skeletal muscle from fasting rats. Over the same time interval of fasting, 1‐[14C]palmitate oxidation remained unchanged. Pyruvate dehydrogenase activity, assayed before in vitro activation, was also reduced in red muscle. Long chain acylcarnitine and long chain acyl CoA increased over the same time period in red muscle. Changes in long chain fatty acid derivatives and pyruvate oxidation were much less dramatic in white muscle. We propose that the rise in levels of long chain fatty acid derivatives may be directly related to the inhibition of carbohydrate oxidation during fasting in red skeletal muscle.",
author = "Carroll, {James Edwin} and Aida Villadiego and Morse, {Daniel P.}",
year = "1983",
month = "1",
day = "1",
doi = "10.1002/mus.880060505",
language = "English (US)",
volume = "6",
pages = "367--373",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Fatty acid oxidation intermediates and the effect of fasting on oxidation in red and white skeletal muscle

AU - Carroll, James Edwin

AU - Villadiego, Aida

AU - Morse, Daniel P.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - In vitro oxidation of U‐[14C]glucose‐6‐phosphate, 2‐[14C]pyruvate, and 1‐[14C]pyruvate was significantly reduced in red skeletal muscle from fasting rats. Over the same time interval of fasting, 1‐[14C]palmitate oxidation remained unchanged. Pyruvate dehydrogenase activity, assayed before in vitro activation, was also reduced in red muscle. Long chain acylcarnitine and long chain acyl CoA increased over the same time period in red muscle. Changes in long chain fatty acid derivatives and pyruvate oxidation were much less dramatic in white muscle. We propose that the rise in levels of long chain fatty acid derivatives may be directly related to the inhibition of carbohydrate oxidation during fasting in red skeletal muscle.

AB - In vitro oxidation of U‐[14C]glucose‐6‐phosphate, 2‐[14C]pyruvate, and 1‐[14C]pyruvate was significantly reduced in red skeletal muscle from fasting rats. Over the same time interval of fasting, 1‐[14C]palmitate oxidation remained unchanged. Pyruvate dehydrogenase activity, assayed before in vitro activation, was also reduced in red muscle. Long chain acylcarnitine and long chain acyl CoA increased over the same time period in red muscle. Changes in long chain fatty acid derivatives and pyruvate oxidation were much less dramatic in white muscle. We propose that the rise in levels of long chain fatty acid derivatives may be directly related to the inhibition of carbohydrate oxidation during fasting in red skeletal muscle.

UR - http://www.scopus.com/inward/record.url?scp=0020563455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020563455&partnerID=8YFLogxK

U2 - 10.1002/mus.880060505

DO - 10.1002/mus.880060505

M3 - Article

C2 - 6136912

AN - SCOPUS:0020563455

VL - 6

SP - 367

EP - 373

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 5

ER -