Feasibility study of lactate imaging of head and neck tumors

E. Adalsteinsson, D. M. Spielman, J. M. Pauly, D. J. Terris, G. Sommer, A. Macovski

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A proton spectroscopic imaging sequence was used to investigate the feasibility of lactate imaging in head and neck tumors. The sequence employs a two-shot lactate editing method with inversion recoverY for additional lipid suppression, and a restricted field of view to suppress motion artifacts. Variations in acquisition parameters and two different receive coils were investigated on twelve patients. Elevated lactate was detected in three patients, no lactate was observed in seven patients, and two studies were inconclusive because of severe motion or inhomogeneity artifacts. Best results were obtained with an anterior/posterior neck coil at a 288 ms echo time (TE).

Original languageEnglish (US)
Pages (from-to)360-369
Number of pages10
JournalNMR in Biomedicine
Volume11
Issue number7
DOIs
Publication statusPublished - Nov 1 1998
Externally publishedYes

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Keywords

  • Head and neck tumors
  • In vivo lactate
  • Lactic acid
  • Spectroscopic imaging
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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