Femoral artery diameter and arteriogenic cytokines in healthy women

Joseph Gerard Cannon, Manning J. Sabatier, Elaina L. Marinik, Earl H. Schwark, Sara Haddow Liebel, Miriam Yvette Cortez-Cooper, Michael F. Bergeron, Gloria Sloan, Kevin K. McCully

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Animal studies have identified monocyte chemoattractive protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) as critical mediators of arterial diameter enlargement in response to chronic increases in blood flow (arteriogenesis). Furthermore, cellular studies have shown that the shear stresses resulting from increased blood flow stimulate synthesis of MCP-1, which in turn stimulates synthesis of VEGF. The purpose of this study was to determine if these mechanisms are evident in healthy women. Resting femoral artery diameter and blood flow, lean leg mass, MCP-1 and VEGF concentrations, and aerobic capacity were measured in 34 healthy women along with plasma concentrations of lipids associated with cardiovascular disease risk. Femoral artery diameter was independently related to metabolically active (lean) leg mass (b = 0.41, P = 0.008) and aerobic capacity (b = 0.45, P = 0.004). Plasma MCP-1 correlated negatively with the ratio of femoral artery diameter to lean leg mass (b = - 0.42, P = 0.009) and positively with serum triglycerides (b = 0.46, P = 0.005). Plasma VEGF exhibited similar correlations and strongly correlated with MCP-1 (R = 0.92, P < 0.0001). The results indicate that circulating MCP-1 and VEGF concentrations are associated with both arteriogenic and atherogenic stimuli in healthy women.

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalVascular Pharmacology
Volume50
Issue number3-4
DOIs
StatePublished - Mar 1 2009

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Femoral Artery
Monocytes
Vascular Endothelial Growth Factor A
Cytokines
Leg
Proteins
Triglycerides
Cardiovascular Diseases
Lipids
Serum

Keywords

  • Arteriogenesis
  • Atherosclerosis
  • Shear rate

ASJC Scopus subject areas

  • Physiology
  • Molecular Medicine
  • Pharmacology

Cite this

Cannon, J. G., Sabatier, M. J., Marinik, E. L., Schwark, E. H., Liebel, S. H., Cortez-Cooper, M. Y., ... McCully, K. K. (2009). Femoral artery diameter and arteriogenic cytokines in healthy women. Vascular Pharmacology, 50(3-4), 104-109. https://doi.org/10.1016/j.vph.2008.11.005

Femoral artery diameter and arteriogenic cytokines in healthy women. / Cannon, Joseph Gerard; Sabatier, Manning J.; Marinik, Elaina L.; Schwark, Earl H.; Liebel, Sara Haddow; Cortez-Cooper, Miriam Yvette; Bergeron, Michael F.; Sloan, Gloria; McCully, Kevin K.

In: Vascular Pharmacology, Vol. 50, No. 3-4, 01.03.2009, p. 104-109.

Research output: Contribution to journalArticle

Cannon, JG, Sabatier, MJ, Marinik, EL, Schwark, EH, Liebel, SH, Cortez-Cooper, MY, Bergeron, MF, Sloan, G & McCully, KK 2009, 'Femoral artery diameter and arteriogenic cytokines in healthy women', Vascular Pharmacology, vol. 50, no. 3-4, pp. 104-109. https://doi.org/10.1016/j.vph.2008.11.005
Cannon JG, Sabatier MJ, Marinik EL, Schwark EH, Liebel SH, Cortez-Cooper MY et al. Femoral artery diameter and arteriogenic cytokines in healthy women. Vascular Pharmacology. 2009 Mar 1;50(3-4):104-109. https://doi.org/10.1016/j.vph.2008.11.005
Cannon, Joseph Gerard ; Sabatier, Manning J. ; Marinik, Elaina L. ; Schwark, Earl H. ; Liebel, Sara Haddow ; Cortez-Cooper, Miriam Yvette ; Bergeron, Michael F. ; Sloan, Gloria ; McCully, Kevin K. / Femoral artery diameter and arteriogenic cytokines in healthy women. In: Vascular Pharmacology. 2009 ; Vol. 50, No. 3-4. pp. 104-109.
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