Femoral artery remodeling after aerobic exercise training without weight loss in women

Manning J. Sabatier, Earl H. Schwark, Richard Lewis, Gloria Sloan, Joseph Gerard Cannon, Kevin McCully

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background. It is currently unclear whether reductions in adiposity mediate the improvements in vascular health that occur with aerobic exercise. The purpose of this longitudinal study of 13 healthy women (33 ± 4 years old) was to determine whether 14 weeks of aerobic exercise would alter functional measures of vascular health, namely resting aortic pulse wave velocity (aPWV, an index of arterial stiffness), femoral artery diameter (DFA), and femoral artery blood flow (BFFA) independent of changes in adiposity. Methods. Aerobic fitness was assessed as VO2peak normalized to fat-free mass, and adiposity (percent body fat) was determined by dual energy x-ray absorptiometry. Serum concentrations of proteins associated with risk for cardiovascular disease, including C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), and leptin, were also measured. Subjects cycled for 50 minutes, 3 times per week. Results. Aerobic fitness normalized to fat-free mass increased 6% (P = 0.03) whereas adiposity did not change. Resting DFAincreased 12% (P < 0.001) and resting shear rate decreased 28% (P = 0.007). Aortic PWV, and serum sICAM-1, CRP and leptin did not change with training. Conclusion. Significant reductions in adiposity were not necessary for aerobic exercise training to bring about improvements in aerobic fitness and arterial remodeling. Peripheral arterial remodeling occurred without changes in central arterial stiffness or markers of inflammation.

Original languageEnglish (US)
Article number13
JournalDynamic Medicine
Volume7
Issue number1
DOIs
StatePublished - Oct 1 2008

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Adiposity
Femoral Artery
Weight Loss
Exercise
Vascular Stiffness
Intercellular Adhesion Molecule-1
Leptin
C-Reactive Protein
Blood Vessels
Fats
Pulse Wave Analysis
Health
Longitudinal Studies
Adipose Tissue
Blood Proteins
Cardiovascular Diseases
X-Rays
Inflammation
Serum

ASJC Scopus subject areas

  • Physiology
  • Orthopedics and Sports Medicine

Cite this

Sabatier, M. J., Schwark, E. H., Lewis, R., Sloan, G., Cannon, J. G., & McCully, K. (2008). Femoral artery remodeling after aerobic exercise training without weight loss in women. Dynamic Medicine, 7(1), [13]. https://doi.org/10.1186/1476-5918-7-13

Femoral artery remodeling after aerobic exercise training without weight loss in women. / Sabatier, Manning J.; Schwark, Earl H.; Lewis, Richard; Sloan, Gloria; Cannon, Joseph Gerard; McCully, Kevin.

In: Dynamic Medicine, Vol. 7, No. 1, 13, 01.10.2008.

Research output: Contribution to journalArticle

Sabatier, MJ, Schwark, EH, Lewis, R, Sloan, G, Cannon, JG & McCully, K 2008, 'Femoral artery remodeling after aerobic exercise training without weight loss in women', Dynamic Medicine, vol. 7, no. 1, 13. https://doi.org/10.1186/1476-5918-7-13
Sabatier, Manning J. ; Schwark, Earl H. ; Lewis, Richard ; Sloan, Gloria ; Cannon, Joseph Gerard ; McCully, Kevin. / Femoral artery remodeling after aerobic exercise training without weight loss in women. In: Dynamic Medicine. 2008 ; Vol. 7, No. 1.
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