Ferroportin q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption

Victor R. Gordeuk, Sharmin F. Diaz, Gladys O. Onojobi, Ishmael Kasvosve, Zufan Debebe, Amanuel Edossa, Jeremy Mark Pantin, Shigang Xiong, Sergei Nekhai, Mehdi Nouraie, Hidekazu Tsukamoto, Robert E. Taylor

Research output: Contribution to journalArticle

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Abstract

Background: Alcohol consumption is associated with increased iron stores. In sub-Saharan Africa, high dietary ionic iron and the ferroportin Q248H allele have also been implicated in iron accumulation. We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans. Methods: Inner-city African-Americans (103 men, 40 women) were recruited from the community according to reported ingestion of >4 alcoholic drinks/d or <2/wk. Typical daily heme iron, nonheme iron and alcohol were estimated using University of Hawaii's multiethnic dietary questionnaire. Based on dietary questionnaire estimates we established categories of < versus ≥56 g alcohol/d, equivalent to 4 alcoholic drinks/d assuming 14 g alcohol per drink. Results: Among 143 participants, 77% drank <56 g alcohol/d and 23%≥56 g/d as estimated by the questionnaire. The prevalence of ferroportin Q248H was 23.3% with alcohol >56 g/d versus 7.5% with lower amounts (p = 0.014). Among subjects with no history of HIV disease, serum ferritin concentration had positive relationships with male gender (p = 0.041), alcohol consumption (p = 0.021) and ALT concentration (p = 0.0001) but not with dietary iron intake or ferroportin Q248H. Serum AST and ALT concentrations had significant positive associations with male gender and hepatitis C seropositivity but not with alcohol or dietary iron intake or ferroportin Q248H. Conclusions: Our findings suggest a higher prevalence of ferroportin Q248H with greater alcohol consumption, and this higher prevalence raises the possibility that the allele might ameliorate the toxicity of alcohol. Our results suggest that alcohol but not dietary iron contributes to higher body iron stores in African-Americans. Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption.

Original languageEnglish (US)
Pages (from-to)1947-1953
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2008

Fingerprint

Dietary Iron
Ferritins
Alcohol Drinking
African Americans
Alcohols
Serum
Alanine
Iron
Aspartic Acid
Alleles
Toxicity
Africa South of the Sahara
Hepatitis C
metal transporting protein 1
Eating
HIV

Keywords

  • Alcohol
  • Dietary iron
  • Ferritin
  • Ferroportin
  • Hepatitis C

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Ferroportin q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. / Gordeuk, Victor R.; Diaz, Sharmin F.; Onojobi, Gladys O.; Kasvosve, Ishmael; Debebe, Zufan; Edossa, Amanuel; Pantin, Jeremy Mark; Xiong, Shigang; Nekhai, Sergei; Nouraie, Mehdi; Tsukamoto, Hidekazu; Taylor, Robert E.

In: Alcoholism: Clinical and Experimental Research, Vol. 32, No. 11, 01.11.2008, p. 1947-1953.

Research output: Contribution to journalArticle

Gordeuk, VR, Diaz, SF, Onojobi, GO, Kasvosve, I, Debebe, Z, Edossa, A, Pantin, JM, Xiong, S, Nekhai, S, Nouraie, M, Tsukamoto, H & Taylor, RE 2008, 'Ferroportin q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption', Alcoholism: Clinical and Experimental Research, vol. 32, no. 11, pp. 1947-1953. https://doi.org/10.1111/j.1530-0277.2008.00782.x
Gordeuk, Victor R. ; Diaz, Sharmin F. ; Onojobi, Gladys O. ; Kasvosve, Ishmael ; Debebe, Zufan ; Edossa, Amanuel ; Pantin, Jeremy Mark ; Xiong, Shigang ; Nekhai, Sergei ; Nouraie, Mehdi ; Tsukamoto, Hidekazu ; Taylor, Robert E. / Ferroportin q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. In: Alcoholism: Clinical and Experimental Research. 2008 ; Vol. 32, No. 11. pp. 1947-1953.
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abstract = "Background: Alcohol consumption is associated with increased iron stores. In sub-Saharan Africa, high dietary ionic iron and the ferroportin Q248H allele have also been implicated in iron accumulation. We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans. Methods: Inner-city African-Americans (103 men, 40 women) were recruited from the community according to reported ingestion of >4 alcoholic drinks/d or <2/wk. Typical daily heme iron, nonheme iron and alcohol were estimated using University of Hawaii's multiethnic dietary questionnaire. Based on dietary questionnaire estimates we established categories of < versus ≥56 g alcohol/d, equivalent to 4 alcoholic drinks/d assuming 14 g alcohol per drink. Results: Among 143 participants, 77{\%} drank <56 g alcohol/d and 23{\%}≥56 g/d as estimated by the questionnaire. The prevalence of ferroportin Q248H was 23.3{\%} with alcohol >56 g/d versus 7.5{\%} with lower amounts (p = 0.014). Among subjects with no history of HIV disease, serum ferritin concentration had positive relationships with male gender (p = 0.041), alcohol consumption (p = 0.021) and ALT concentration (p = 0.0001) but not with dietary iron intake or ferroportin Q248H. Serum AST and ALT concentrations had significant positive associations with male gender and hepatitis C seropositivity but not with alcohol or dietary iron intake or ferroportin Q248H. Conclusions: Our findings suggest a higher prevalence of ferroportin Q248H with greater alcohol consumption, and this higher prevalence raises the possibility that the allele might ameliorate the toxicity of alcohol. Our results suggest that alcohol but not dietary iron contributes to higher body iron stores in African-Americans. Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption.",
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T1 - Ferroportin q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption

AU - Gordeuk, Victor R.

AU - Diaz, Sharmin F.

AU - Onojobi, Gladys O.

AU - Kasvosve, Ishmael

AU - Debebe, Zufan

AU - Edossa, Amanuel

AU - Pantin, Jeremy Mark

AU - Xiong, Shigang

AU - Nekhai, Sergei

AU - Nouraie, Mehdi

AU - Tsukamoto, Hidekazu

AU - Taylor, Robert E.

PY - 2008/11/1

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N2 - Background: Alcohol consumption is associated with increased iron stores. In sub-Saharan Africa, high dietary ionic iron and the ferroportin Q248H allele have also been implicated in iron accumulation. We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans. Methods: Inner-city African-Americans (103 men, 40 women) were recruited from the community according to reported ingestion of >4 alcoholic drinks/d or <2/wk. Typical daily heme iron, nonheme iron and alcohol were estimated using University of Hawaii's multiethnic dietary questionnaire. Based on dietary questionnaire estimates we established categories of < versus ≥56 g alcohol/d, equivalent to 4 alcoholic drinks/d assuming 14 g alcohol per drink. Results: Among 143 participants, 77% drank <56 g alcohol/d and 23%≥56 g/d as estimated by the questionnaire. The prevalence of ferroportin Q248H was 23.3% with alcohol >56 g/d versus 7.5% with lower amounts (p = 0.014). Among subjects with no history of HIV disease, serum ferritin concentration had positive relationships with male gender (p = 0.041), alcohol consumption (p = 0.021) and ALT concentration (p = 0.0001) but not with dietary iron intake or ferroportin Q248H. Serum AST and ALT concentrations had significant positive associations with male gender and hepatitis C seropositivity but not with alcohol or dietary iron intake or ferroportin Q248H. Conclusions: Our findings suggest a higher prevalence of ferroportin Q248H with greater alcohol consumption, and this higher prevalence raises the possibility that the allele might ameliorate the toxicity of alcohol. Our results suggest that alcohol but not dietary iron contributes to higher body iron stores in African-Americans. Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption.

AB - Background: Alcohol consumption is associated with increased iron stores. In sub-Saharan Africa, high dietary ionic iron and the ferroportin Q248H allele have also been implicated in iron accumulation. We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans. Methods: Inner-city African-Americans (103 men, 40 women) were recruited from the community according to reported ingestion of >4 alcoholic drinks/d or <2/wk. Typical daily heme iron, nonheme iron and alcohol were estimated using University of Hawaii's multiethnic dietary questionnaire. Based on dietary questionnaire estimates we established categories of < versus ≥56 g alcohol/d, equivalent to 4 alcoholic drinks/d assuming 14 g alcohol per drink. Results: Among 143 participants, 77% drank <56 g alcohol/d and 23%≥56 g/d as estimated by the questionnaire. The prevalence of ferroportin Q248H was 23.3% with alcohol >56 g/d versus 7.5% with lower amounts (p = 0.014). Among subjects with no history of HIV disease, serum ferritin concentration had positive relationships with male gender (p = 0.041), alcohol consumption (p = 0.021) and ALT concentration (p = 0.0001) but not with dietary iron intake or ferroportin Q248H. Serum AST and ALT concentrations had significant positive associations with male gender and hepatitis C seropositivity but not with alcohol or dietary iron intake or ferroportin Q248H. Conclusions: Our findings suggest a higher prevalence of ferroportin Q248H with greater alcohol consumption, and this higher prevalence raises the possibility that the allele might ameliorate the toxicity of alcohol. Our results suggest that alcohol but not dietary iron contributes to higher body iron stores in African-Americans. Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption.

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KW - Dietary iron

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KW - Hepatitis C

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