Fever in the elderly. Production of leukocytic pyrogen by monocytes from elderly persons

P. G. Jones, C. A. Kauffman, A. G. Bergman, C. M. Hayes, M. J. Kluger, Joseph Gerard Cannon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In an attempt to explain the diminished febrile response of the elderly, we studied the first step in fever generation, that of production of leukocytic pyrogen (LP) by monocytes. Monocytes from 25 healthy elderly volunteers (ages 65-91) and 24 healthy young volunteers (ages 17-38) were stimulated with Staphylococcus epidermidis to release LP; LP activity in the culture supernatants was assayed by measuring the pyrogenic response in rabbits and rats and the fall in plasma iron and zinc in rats. Monocytes from elderly volunteers produced slightly less LP than monocytes from young volunteers, but the difference was not statistically significant. The amount of LP produced was not correlated with age. Therefore, the diminished febrile response of the elderly is not the result of an intrinsic defect in the monocyte's ability to make LP. Other explanations relating to the central effect of LP and the effector response to LP in the elderly should be sought.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalGerontology
Volume30
Issue number3
DOIs
StatePublished - Jan 1 1984

Fingerprint

Pyrogens
Monocytes
Fever
Volunteers
Healthy Volunteers
Staphylococcus epidermidis
Zinc
Iron
Rabbits

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Jones, P. G., Kauffman, C. A., Bergman, A. G., Hayes, C. M., Kluger, M. J., & Cannon, J. G. (1984). Fever in the elderly. Production of leukocytic pyrogen by monocytes from elderly persons. Gerontology, 30(3), 182-187. https://doi.org/10.1159/000212627

Fever in the elderly. Production of leukocytic pyrogen by monocytes from elderly persons. / Jones, P. G.; Kauffman, C. A.; Bergman, A. G.; Hayes, C. M.; Kluger, M. J.; Cannon, Joseph Gerard.

In: Gerontology, Vol. 30, No. 3, 01.01.1984, p. 182-187.

Research output: Contribution to journalArticle

Jones, PG, Kauffman, CA, Bergman, AG, Hayes, CM, Kluger, MJ & Cannon, JG 1984, 'Fever in the elderly. Production of leukocytic pyrogen by monocytes from elderly persons', Gerontology, vol. 30, no. 3, pp. 182-187. https://doi.org/10.1159/000212627
Jones PG, Kauffman CA, Bergman AG, Hayes CM, Kluger MJ, Cannon JG. Fever in the elderly. Production of leukocytic pyrogen by monocytes from elderly persons. Gerontology. 1984 Jan 1;30(3):182-187. https://doi.org/10.1159/000212627
Jones, P. G. ; Kauffman, C. A. ; Bergman, A. G. ; Hayes, C. M. ; Kluger, M. J. ; Cannon, Joseph Gerard. / Fever in the elderly. Production of leukocytic pyrogen by monocytes from elderly persons. In: Gerontology. 1984 ; Vol. 30, No. 3. pp. 182-187.
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