Fibromuscular Dysplasia: An Uncommon Cause of Secondary Hypertension

L. Michael Prisant, Harold M. Szerlip, Laura L. Mulloy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Fibromuscular dysplasia is a noninflammatory vascular disease that commonly affects the distal two thirds of the renal artery and branch vessels, but occasionally involves other arteries. Progression of stenosis occurs in 16%–38% of renal arteries. Although the etiology is unknown, genetic studies suggest a relationship to the angiotensin-converting enzyme I allele. Thin, young Caucasian women without a family history of hypertension are most commonly affected. An abdominal or flank systolic-diastolic bruit is an important clue for the diagnosis. Most noninvasive screening tests are not sensitive or reproducible to be used to rule out renal artery stenosis, but digital subtraction renal angiography usually confirms the diagnosis. Percutaneous renal artery angioplasty is the treatment of choice, but may not result in normalization of blood pressure if diagnosis is delayed. Since restenosis occurs, continued follow-up is necessary.

Original languageEnglish (US)
Pages (from-to)894-898
Number of pages5
JournalJournal of Clinical Hypertension
Volume8
Issue number12
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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