TY - JOUR
T1 - Fibromuscular Dysplasia
T2 - An Uncommon Cause of Secondary Hypertension
AU - Prisant, L. Michael
AU - Szerlip, Harold M.
AU - Mulloy, Laura L.
N1 - Publisher Copyright:
© 2006 Wiley. All rights reserved.
PY - 2006
Y1 - 2006
N2 - Fibromuscular dysplasia is a noninflammatory vascular disease that commonly affects the distal two thirds of the renal artery and branch vessels, but occasionally involves other arteries. Progression of stenosis occurs in 16%–38% of renal arteries. Although the etiology is unknown, genetic studies suggest a relationship to the angiotensin-converting enzyme I allele. Thin, young Caucasian women without a family history of hypertension are most commonly affected. An abdominal or flank systolic-diastolic bruit is an important clue for the diagnosis. Most noninvasive screening tests are not sensitive or reproducible to be used to rule out renal artery stenosis, but digital subtraction renal angiography usually confirms the diagnosis. Percutaneous renal artery angioplasty is the treatment of choice, but may not result in normalization of blood pressure if diagnosis is delayed. Since restenosis occurs, continued follow-up is necessary.
AB - Fibromuscular dysplasia is a noninflammatory vascular disease that commonly affects the distal two thirds of the renal artery and branch vessels, but occasionally involves other arteries. Progression of stenosis occurs in 16%–38% of renal arteries. Although the etiology is unknown, genetic studies suggest a relationship to the angiotensin-converting enzyme I allele. Thin, young Caucasian women without a family history of hypertension are most commonly affected. An abdominal or flank systolic-diastolic bruit is an important clue for the diagnosis. Most noninvasive screening tests are not sensitive or reproducible to be used to rule out renal artery stenosis, but digital subtraction renal angiography usually confirms the diagnosis. Percutaneous renal artery angioplasty is the treatment of choice, but may not result in normalization of blood pressure if diagnosis is delayed. Since restenosis occurs, continued follow-up is necessary.
UR - http://www.scopus.com/inward/record.url?scp=34648873734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34648873734&partnerID=8YFLogxK
U2 - 10.1111/j.1524-6175.2006.06021.x
DO - 10.1111/j.1524-6175.2006.06021.x
M3 - Article
C2 - 17170616
AN - SCOPUS:34648873734
SN - 1524-6175
VL - 8
SP - 894
EP - 898
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 12
ER -