Fine mapping of the PTGFR gene to 1p31 region and mutation analysis in human breast cancer.

K. Sossey-Alaoui, E. Kitamura, John Kenneth Cowell

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The 1p31 chromosomal region shows loss of heterozygosity (LOH) in up to 50% of human breast cancer, indicating the presence of a tumor suppressor gene at this location. Many efforts have been made to identify candidate genes responsible for breast cancer on the short arm of chromosome 1. It was shown that prostaglandins have been implicated in the tumorigenesis pathway, perhaps via interactions with their cell surface receptors. The prostaglandin F2 receptor gene (PTGFR) was tentatively mapped to 1p31 adjacent to the region undergoing LOH in human breast cancer. We undertook a mutation study in 34 sporadic human breast tumors using a variant of SSCP, incorporation PCR SSCP (IPS). Several nucleotide variants were detected in different tumors. Here we report the nature of these nucleotide changes and the possible involvement of the PTGFR gene in the etiology of human cancer.

Original languageEnglish (US)
Pages (from-to)543-546
Number of pages4
JournalInternational Journal of Molecular Medicine
Volume7
Issue number5
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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