Fingernail Fluoride

A Method for Monitoring Fluoride Exposure

Gary M. Whitford, F. C. Sampaio, P. Arneberg, F. R. Von Der Fehr

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

This work was based on the hypothesis that fingernail clippings can be used as a biomarker for the subchronic exposure to fluoride. The results provide data on factors that may affect the concentration of fluoride in fingernail clippings as determined with the electrode following HMDS-facilitated diffusion. The following variables had only minor or no effects on the concentrations: (1) the surface area of the clippings (intact, minced or filed into powder) that were placed into the diffusion dishes; (2) soaking in deionized water for up to 6 h; (3) soaking in fluoridated water (1.0 ppm) for 2 h, and (4) removal of the organic material of nails by dry ashing. Fingernail fluoride concentrations were approximately 50% higher than those in toenails. A 1-month period of increased fluoride intake by one of the authors resulted in significant increases in fingernail fluoride concentrations after a lag time of approximately 3.5 months. The fluoride concentrations in fingernail clippings obtained from three groups of Brazilian children were directly related to the concentrations in the drinking water (0.1, 1.6 or 2.3 ppm). The results indicate that: (1) HMDS-facilitated diffusion completely separates fluoride from intact nail clippings, so the need for ashing or other preparative methods is obviated; (2) fingernail fluoride is derived mainly from the systemic circulation, and (3) fluoride intake is reflected by the concentrations in fingernails.

Original languageEnglish (US)
Pages (from-to)462-467
Number of pages6
JournalCaries Research
Volume33
Issue number6
DOIs
StatePublished - Nov 1 1999

Fingerprint

Nails
Fluorides
Facilitated Diffusion
Water
Drinking Water
Powders
Electrodes
Biomarkers

Keywords

  • Biomarker
  • Exposure
  • Fingernails
  • Fluoride
  • Intake
  • Toenails

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Fingernail Fluoride : A Method for Monitoring Fluoride Exposure. / Whitford, Gary M.; Sampaio, F. C.; Arneberg, P.; Von Der Fehr, F. R.

In: Caries Research, Vol. 33, No. 6, 01.11.1999, p. 462-467.

Research output: Contribution to journalArticle

Whitford, GM, Sampaio, FC, Arneberg, P & Von Der Fehr, FR 1999, 'Fingernail Fluoride: A Method for Monitoring Fluoride Exposure', Caries Research, vol. 33, no. 6, pp. 462-467. https://doi.org/10.1159/000016552
Whitford, Gary M. ; Sampaio, F. C. ; Arneberg, P. ; Von Der Fehr, F. R. / Fingernail Fluoride : A Method for Monitoring Fluoride Exposure. In: Caries Research. 1999 ; Vol. 33, No. 6. pp. 462-467.
@article{05557d14c3fa4c09b956c57e210b6d21,
title = "Fingernail Fluoride: A Method for Monitoring Fluoride Exposure",
abstract = "This work was based on the hypothesis that fingernail clippings can be used as a biomarker for the subchronic exposure to fluoride. The results provide data on factors that may affect the concentration of fluoride in fingernail clippings as determined with the electrode following HMDS-facilitated diffusion. The following variables had only minor or no effects on the concentrations: (1) the surface area of the clippings (intact, minced or filed into powder) that were placed into the diffusion dishes; (2) soaking in deionized water for up to 6 h; (3) soaking in fluoridated water (1.0 ppm) for 2 h, and (4) removal of the organic material of nails by dry ashing. Fingernail fluoride concentrations were approximately 50{\%} higher than those in toenails. A 1-month period of increased fluoride intake by one of the authors resulted in significant increases in fingernail fluoride concentrations after a lag time of approximately 3.5 months. The fluoride concentrations in fingernail clippings obtained from three groups of Brazilian children were directly related to the concentrations in the drinking water (0.1, 1.6 or 2.3 ppm). The results indicate that: (1) HMDS-facilitated diffusion completely separates fluoride from intact nail clippings, so the need for ashing or other preparative methods is obviated; (2) fingernail fluoride is derived mainly from the systemic circulation, and (3) fluoride intake is reflected by the concentrations in fingernails.",
keywords = "Biomarker, Exposure, Fingernails, Fluoride, Intake, Toenails",
author = "Whitford, {Gary M.} and Sampaio, {F. C.} and P. Arneberg and {Von Der Fehr}, {F. R.}",
year = "1999",
month = "11",
day = "1",
doi = "10.1159/000016552",
language = "English (US)",
volume = "33",
pages = "462--467",
journal = "Caries Research",
issn = "0008-6568",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Fingernail Fluoride

T2 - A Method for Monitoring Fluoride Exposure

AU - Whitford, Gary M.

AU - Sampaio, F. C.

AU - Arneberg, P.

AU - Von Der Fehr, F. R.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - This work was based on the hypothesis that fingernail clippings can be used as a biomarker for the subchronic exposure to fluoride. The results provide data on factors that may affect the concentration of fluoride in fingernail clippings as determined with the electrode following HMDS-facilitated diffusion. The following variables had only minor or no effects on the concentrations: (1) the surface area of the clippings (intact, minced or filed into powder) that were placed into the diffusion dishes; (2) soaking in deionized water for up to 6 h; (3) soaking in fluoridated water (1.0 ppm) for 2 h, and (4) removal of the organic material of nails by dry ashing. Fingernail fluoride concentrations were approximately 50% higher than those in toenails. A 1-month period of increased fluoride intake by one of the authors resulted in significant increases in fingernail fluoride concentrations after a lag time of approximately 3.5 months. The fluoride concentrations in fingernail clippings obtained from three groups of Brazilian children were directly related to the concentrations in the drinking water (0.1, 1.6 or 2.3 ppm). The results indicate that: (1) HMDS-facilitated diffusion completely separates fluoride from intact nail clippings, so the need for ashing or other preparative methods is obviated; (2) fingernail fluoride is derived mainly from the systemic circulation, and (3) fluoride intake is reflected by the concentrations in fingernails.

AB - This work was based on the hypothesis that fingernail clippings can be used as a biomarker for the subchronic exposure to fluoride. The results provide data on factors that may affect the concentration of fluoride in fingernail clippings as determined with the electrode following HMDS-facilitated diffusion. The following variables had only minor or no effects on the concentrations: (1) the surface area of the clippings (intact, minced or filed into powder) that were placed into the diffusion dishes; (2) soaking in deionized water for up to 6 h; (3) soaking in fluoridated water (1.0 ppm) for 2 h, and (4) removal of the organic material of nails by dry ashing. Fingernail fluoride concentrations were approximately 50% higher than those in toenails. A 1-month period of increased fluoride intake by one of the authors resulted in significant increases in fingernail fluoride concentrations after a lag time of approximately 3.5 months. The fluoride concentrations in fingernail clippings obtained from three groups of Brazilian children were directly related to the concentrations in the drinking water (0.1, 1.6 or 2.3 ppm). The results indicate that: (1) HMDS-facilitated diffusion completely separates fluoride from intact nail clippings, so the need for ashing or other preparative methods is obviated; (2) fingernail fluoride is derived mainly from the systemic circulation, and (3) fluoride intake is reflected by the concentrations in fingernails.

KW - Biomarker

KW - Exposure

KW - Fingernails

KW - Fluoride

KW - Intake

KW - Toenails

UR - http://www.scopus.com/inward/record.url?scp=0033227729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033227729&partnerID=8YFLogxK

U2 - 10.1159/000016552

DO - 10.1159/000016552

M3 - Article

VL - 33

SP - 462

EP - 467

JO - Caries Research

JF - Caries Research

SN - 0008-6568

IS - 6

ER -