Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype

I. Bakioglu, Y. Hattori, Abdullah Kutlar, C. Mathew, T. H.J. Huisman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (βs chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the βs # 31 chromosome promotes the synthesis of γ chains.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalAmerican Journal of Hematology
Issue number3
StatePublished - Jan 1 1985


  • Hb F
  • SS disease
  • haplotypes
  • α‐thalassemia
  • γ chain composition

ASJC Scopus subject areas

  • Hematology


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