Abstract
Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (βs chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the βs # 31 chromosome promotes the synthesis of γ chains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 297-300 |
| Number of pages | 4 |
| Journal | American Journal of Hematology |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1985 |
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Keywords
- haplotypes
- Hb F
- SS disease
- α‐thalassemia
- γ chain composition
ASJC Scopus subject areas
- Hematology
Cite this
Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype. / Bakioglu, I.; Hattori, Y.; Kutlar, Abdullah; Mathew, C.; Huisman, T. H.J.
In: American Journal of Hematology, Vol. 20, No. 3, 01.01.1985, p. 297-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype
AU - Bakioglu, I.
AU - Hattori, Y.
AU - Kutlar, Abdullah
AU - Mathew, C.
AU - Huisman, T. H.J.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (βs chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the βs # 31 chromosome promotes the synthesis of γ chains.
AB - Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (βs chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the βs # 31 chromosome promotes the synthesis of γ chains.
KW - haplotypes
KW - Hb F
KW - SS disease
KW - α‐thalassemia
KW - γ chain composition
UR - http://www.scopus.com/inward/record.url?scp=0022346791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022346791&partnerID=8YFLogxK
U2 - 10.1002/ajh.2830200313
DO - 10.1002/ajh.2830200313
M3 - Article
VL - 20
SP - 297
EP - 300
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -