Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype

I. Bakioglu, Y. Hattori, Abdullah Kutlar, C. Mathew, T. H.J. Huisman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (βs chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the βs # 31 chromosome promotes the synthesis of γ chains.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalAmerican Journal of Hematology
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1985

Fingerprint

Sickle Cell Anemia
Haplotypes
Chromosomes
Qatar
Thalassemia
South Africa
Turkey
DNA

Keywords

  • Hb F
  • SS disease
  • haplotypes
  • α‐thalassemia
  • γ chain composition

ASJC Scopus subject areas

  • Hematology

Cite this

Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype. / Bakioglu, I.; Hattori, Y.; Kutlar, Abdullah; Mathew, C.; Huisman, T. H.J.

In: American Journal of Hematology, Vol. 20, No. 3, 01.01.1985, p. 297-300.

Research output: Contribution to journalArticle

Bakioglu, I. ; Hattori, Y. ; Kutlar, Abdullah ; Mathew, C. ; Huisman, T. H.J. / Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype. In: American Journal of Hematology. 1985 ; Vol. 20, No. 3. pp. 297-300.
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