TY - CHAP
T1 - Flammer and Sjögren Syndromes
T2 - What and Why Is in Common?
AU - Baban, Babak
AU - Golubnitschaja, Olga
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2019.
PY - 2019
Y1 - 2019
N2 - Flammer syndrome (FS) occurs more frequently in females; its signs and symptoms are mainly linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. To this end, inflammation and immune disorders including autoimmunity are considered as a consequence of the abnormal vascular regulation processes. Decreased thirst feeling typical for FS-affected individuals may lead to extensive body dehydration resulting in increased risks for Sicca syndrome and breast cancer (BC), amongst others. Indeed, recent research demonstrated FS phenotype as being dominant in individuals with “dry mouth” syndrome even at very young age, vaginal dryness in both pre- and post-menopausal women, as well as BC patients with particularly pronounced FS phenotype in case of the aggressive metastatic disease. Further, FS-affected individuals to individual extent may be predisposed to a prolonged wound healing. Sjögren syndrome (SS) is an autoimmune disease characterised by a progressive Sicca syndrome, specific immunologic complex and/or significant infiltrate at minor salivary gland biopsy. SS is relatively frequent, with a clinical diagnosis predominantly amongst women. Its physiopathology is a complex battery of both genetic and environmental risk factors. If left untreated, SS may be associated with and/or may result in impaired wound healing, severe arthritis and development of several cancer types. Further, breast inflammatory patterns were reported in females affected by Sjögren syndrome. In this chapter we summarise the facts and hypotheses connecting FS and SS together and mechanisms potentially overlapping in both syndromes that might be of great clinical value. Multi-professional considerations presented here are an example for how to effectively enter the new era of preventive, predictive and personalised medicine benefiting the patients and healthcare system as the whole.
AB - Flammer syndrome (FS) occurs more frequently in females; its signs and symptoms are mainly linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. To this end, inflammation and immune disorders including autoimmunity are considered as a consequence of the abnormal vascular regulation processes. Decreased thirst feeling typical for FS-affected individuals may lead to extensive body dehydration resulting in increased risks for Sicca syndrome and breast cancer (BC), amongst others. Indeed, recent research demonstrated FS phenotype as being dominant in individuals with “dry mouth” syndrome even at very young age, vaginal dryness in both pre- and post-menopausal women, as well as BC patients with particularly pronounced FS phenotype in case of the aggressive metastatic disease. Further, FS-affected individuals to individual extent may be predisposed to a prolonged wound healing. Sjögren syndrome (SS) is an autoimmune disease characterised by a progressive Sicca syndrome, specific immunologic complex and/or significant infiltrate at minor salivary gland biopsy. SS is relatively frequent, with a clinical diagnosis predominantly amongst women. Its physiopathology is a complex battery of both genetic and environmental risk factors. If left untreated, SS may be associated with and/or may result in impaired wound healing, severe arthritis and development of several cancer types. Further, breast inflammatory patterns were reported in females affected by Sjögren syndrome. In this chapter we summarise the facts and hypotheses connecting FS and SS together and mechanisms potentially overlapping in both syndromes that might be of great clinical value. Multi-professional considerations presented here are an example for how to effectively enter the new era of preventive, predictive and personalised medicine benefiting the patients and healthcare system as the whole.
KW - Autoimmune disease
KW - Breast cancer
KW - Common mechanisms
KW - Environment
KW - Flammer syndrome
KW - Gender
KW - Genetic
KW - Health policy
KW - Inflammation
KW - Patient stratification
KW - Predictive preventive personalied medicine (PPPM)
KW - Reciprocal relationship
KW - Risks
KW - Sicca syndrome
KW - Sjögren syndrome
KW - Stress response
KW - Vascular dysregulation
KW - Wound healing
KW - Xerophthalmia
KW - Xerostomia
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U2 - 10.1007/978-3-030-13550-8_11
DO - 10.1007/978-3-030-13550-8_11
M3 - Chapter
AN - SCOPUS:85114070489
T3 - Advances in Predictive, Preventive and Personalised Medicine
SP - 183
EP - 192
BT - Advances in Predictive, Preventive and Personalised Medicine
PB - Springer Science and Business Media B.V.
ER -