Flavonoids and biological activities of Jussiaea repens

M. S. Marzouk; F. M. Soliman; I. A. Shehata; M. Rabee; G. A. Fawzy

doi:10.1080/14786410600943288

Flavonoids and biological activities of Jussiaea repens

M. S. Marzouk, F. M. Soliman, I. A. Shehata, M. Rabee, G. A. Fawzy

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A new acylated avicularin, namely avicularin 2″-(4″-O-n-pentanoyl)-gallate (1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. (Onagraceae). Their structures were established as trifolin 2″-O-gallate (2), quercetrin (3), guaijaverin (4), reynoutrin (5), juglanin (6), avicularin (7), hyperin (8), trifolin (9), hyperin 2″-O-gallate (10), rutin (11), kaempferol (12) and quercetin (13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD₅₀ up to the maximum soluble dose 4 g kg^-1 body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.

Original language	English (US)
Pages (from-to)	436-443
Number of pages	8
Journal	Natural Product Research
Volume	21
Issue number	5
DOIs	https://doi.org/10.1080/14786410600943288
State	Published - May 1 2007
Externally published	Yes

Keywords

Aerial parts
Anti-inflammatory activity
Antidiabetic activity
Hepatoprotective activity
Jussiaea repens
Onagraceae
Quercetin and kaempferol 3-O-glycosides

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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title = "Flavonoids and biological activities of Jussiaea repens",

abstract = "A new acylated avicularin, namely avicularin 2″-(4″-O-n-pentanoyl)-gallate (1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. (Onagraceae). Their structures were established as trifolin 2″-O-gallate (2), quercetrin (3), guaijaverin (4), reynoutrin (5), juglanin (6), avicularin (7), hyperin (8), trifolin (9), hyperin 2″-O-gallate (10), rutin (11), kaempferol (12) and quercetin (13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD50 up to the maximum soluble dose 4 g kg-1 body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.",

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AU - Soliman, F. M.

AU - Shehata, I. A.

AU - Rabee, M.

AU - Fawzy, G. A.

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