Flavonoids and biological activities of Jussiaea repens

M. S. Marzouk, F. M. Soliman, I. A. Shehata, M. Rabee, G. A. Fawzy

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A new acylated avicularin, namely avicularin 2″-(4″-O-n-pentanoyl)-gallate (1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. (Onagraceae). Their structures were established as trifolin 2″-O-gallate (2), quercetrin (3), guaijaverin (4), reynoutrin (5), juglanin (6), avicularin (7), hyperin (8), trifolin (9), hyperin 2″-O-gallate (10), rutin (11), kaempferol (12) and quercetin (13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD50 up to the maximum soluble dose 4 g kg-1 body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.

Original languageEnglish (US)
Pages (from-to)436-443
Number of pages8
JournalNatural Product Research
Volume21
Issue number5
DOIs
StatePublished - May 1 2007
Externally publishedYes

Keywords

  • Aerial parts
  • Anti-inflammatory activity
  • Antidiabetic activity
  • Hepatoprotective activity
  • Jussiaea repens
  • Onagraceae
  • Quercetin and kaempferol 3-O-glycosides

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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