Abstract
A new acylated avicularin, namely avicularin 2″-(4″-O-n-pentanoyl)-gallate (1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. (Onagraceae). Their structures were established as trifolin 2″-O-gallate (2), quercetrin (3), guaijaverin (4), reynoutrin (5), juglanin (6), avicularin (7), hyperin (8), trifolin (9), hyperin 2″-O-gallate (10), rutin (11), kaempferol (12) and quercetin (13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD50 up to the maximum soluble dose 4 g kg-1 body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.
Original language | English (US) |
---|---|
Pages (from-to) | 436-443 |
Number of pages | 8 |
Journal | Natural Product Research |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2007 |
Externally published | Yes |
Keywords
- Aerial parts
- Anti-inflammatory activity
- Antidiabetic activity
- Hepatoprotective activity
- Jussiaea repens
- Onagraceae
- Quercetin and kaempferol 3-O-glycosides
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry