Fluorescein Angiographic Defects of the Optic Disc in Glaucoma

Bernard Schwartz, John C. Rieser, Sumner L. Fishbein

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


An Improved technique for high-contrast, high-resolution fluorescein angiography of the optic disc has been developed that almost eliminates pseudo-fluorescence. Fluorescein angiography of the optic disc was performed on normal, ocular hypertensive, and glaucomatous patients. Rapid-sequence angiograms in the early arterial phases have demonstrated localized areas of hypofluorescence or filling defects of the optic disc. Two types of fluorescein filling defects were observed—absolute and relative. The number of absolute filling defects, which increased with degree of visual field loss, was greater in glaucomatous than in ocular hypertensive or normal eyes. Similarly, ocular hypertensive eyes showed a larger number of discs with filling defects than normal eyes. It is postulated that relative defects progress to absolute filling defects, which may be an indication of impending loss of visual field.

Original languageEnglish (US)
Pages (from-to)1961-1974
Number of pages14
JournalArchives of Ophthalmology
Issue number11
StatePublished - Nov 1977
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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