Fluoride Absorption

Independence from Plasma Fluoride Levels

Gary M. Whitford, Jerry L. Williams

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The concept that there are physiologic mechanisms to homeostatically regulate plasma fluoride concentrations has been supported by results in the literature suggesting an inverse relationship between plasma fluoride levels and the absorption of the ion from the gastrointestinal tract of the rat. The validity of the relationship was questioned because of possible problems in the experimental design. The present work used four different methods to evaluate the effect of plasma fluoride levels on the absorption of the ion in rats: (i) the percentage of the daily fluoride intake that was excreted in the urine; (ii) the concentration of fluoride in femur epiphyses; (iii) the net areas under the time-plasma fluoride concentration curves after intragastric fluoride doses; and (iv) the residual amounts of fluoride in the gastrointestinal tracts after the intragastric fluoride doses. None of these methods indicated that plasma fluoride levels influence the rate or the degree of fluoride absorption. It was concluded that, unless extremely high plasma fluoride levels are involved (pharmacologic or toxic doses), the absorption of the ion is independent of plasma levels. The results provide further evidence that plasma fluoride concentrations are not homeostatically regulated.

Original languageEnglish (US)
Pages (from-to)550-554
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume181
Issue number4
DOIs
StatePublished - Jan 1 1986

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Fluorides
Plasmas
Ions
Gastrointestinal Tract
Rats
Epiphyses
Poisons
Femur
Design of experiments
Research Design
Urine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fluoride Absorption : Independence from Plasma Fluoride Levels. / Whitford, Gary M.; Williams, Jerry L.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 181, No. 4, 01.01.1986, p. 550-554.

Research output: Contribution to journalArticle

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