Fluoride absorption through the hamster cheek pouch: A pH‐dependent event

G. M. Whitford, R. S. Callan, H. S. Wang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The fractional absorptions of fluoride, 3H2O, 125I and 14C‐DMO from the hamster cheek pouch were determined as functions of solution pH. When the pH was ≥5, fluoride absorption rate was inversely related to pH. The absorption rates of the other substances were not influenced by pH. The fractional absorptions of fluoride and 3H2O were independent of fluoride concentrations over the range 1–53 mM. The data indicate that the absorption of fluoride through this keratinized epithelium occurs mainly by the diffusion of non‐ionic HF.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalJournal of Applied Toxicology
Issue number6
StatePublished - Dec 1982


  • hydrogen fluoride (HF)
  • metabolism
  • oral absorption

ASJC Scopus subject areas

  • Toxicology


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