Fluoride absorption through the hamster cheek pouch: A pH‐dependent event

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The fractional absorptions of fluoride, 3H2O, 125I and 14C‐DMO from the hamster cheek pouch were determined as functions of solution pH. When the pH was ≥5, fluoride absorption rate was inversely related to pH. The absorption rates of the other substances were not influenced by pH. The fractional absorptions of fluoride and 3H2O were independent of fluoride concentrations over the range 1–53 mM. The data indicate that the absorption of fluoride through this keratinized epithelium occurs mainly by the diffusion of non‐ionic HF.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalJournal of Applied Toxicology
Volume2
Issue number6
DOIs
StatePublished - Jan 1 1982

Fingerprint

Cheek
Fluorides
Cricetinae
Epithelium

Keywords

  • hydrogen fluoride (HF)
  • metabolism
  • oral absorption

ASJC Scopus subject areas

  • Toxicology

Cite this

Fluoride absorption through the hamster cheek pouch : A pH‐dependent event. / Whitford, Gary M.; Callan, Richard S; Wang, H. S.

In: Journal of Applied Toxicology, Vol. 2, No. 6, 01.01.1982, p. 303-306.

Research output: Contribution to journalArticle

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AB - The fractional absorptions of fluoride, 3H2O, 125I and 14C‐DMO from the hamster cheek pouch were determined as functions of solution pH. When the pH was ≥5, fluoride absorption rate was inversely related to pH. The absorption rates of the other substances were not influenced by pH. The fractional absorptions of fluoride and 3H2O were independent of fluoride concentrations over the range 1–53 mM. The data indicate that the absorption of fluoride through this keratinized epithelium occurs mainly by the diffusion of non‐ionic HF.

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