Fluoride, calcium and phosphorus metabolism in the rat: Comparison of 'natural ingredient' with semipurified diets

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Three groups of weanling female rats were fed different, commercially available, 'natural ingredient' diets containing 12, 28 or 45 parts/106 F, mainly as bone meal, for six weeks. Two other groups were fed a low-fluoride (0.76 parts/106) semipurified diet. They received fluoride doses, either in the drinking water or by daily intraperitoneal injection, which were approximately equal to the average dose of the other three groups. Rats on the 'natural ingredient' diets ingested more food and water and excreted more faeces arid urine, effects which were attributed to the higher amounts of dietary fibre, Na, K and Cl. Thus, at any given concentration of fluoride in the food or water, the level of fluoride ingestion and the ensuing effects would be influenced by the type of diet used. The values for fractional fluoride absorption (45-49%) and retention (38-47%) were similar among the groups given 'natural ingredient' diets. In the groups given semipurified diet, the corresponding values were about twice as high with the exception that fractional absorption was negative (-41%) in the injected group, which indicated net intestinal secretion of fluoride. Fluoride balances and tissue concentrations were highest in the groups fed the semipurified diet, even though the level of intake was not always higher. The fractional values for calcium and phosphorus absorption (41-51%) and retention (33-43%) were also similar among the groups given 'natural ingredient' diets. The corresponding values were about twice as high in the groups fed the semipurified diet. In terms of supporting maximum bone calcification, phosphorus absorption was marginal in two of the groups on the 'natural ingredient' diets. Because of their variable fluoride concentrations and ill-defined compositions, the use of 'natural ingredient' diets in research should be avoided.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalArchives of Oral Biology
Volume36
Issue number4
DOIs
StatePublished - 1991

Fingerprint

Calcium Fluoride
Phosphorus
Fluorides
Diet
Intestinal Secretions
Food
Water
Dietary Fiber
Intraperitoneal Injections
Feces
Drinking Water

Keywords

  • absorption
  • balance
  • bone fluoride
  • bone mineralization
  • cAMP
  • dental fluorosis
  • enamel fluoride
  • enamel mineralization
  • faecal excretion
  • intake
  • osteoporosis
  • plasma fluoride
  • retention
  • urinary excretion

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

@article{9160a93de78e45479a57ada34b0323a6,
title = "Fluoride, calcium and phosphorus metabolism in the rat: Comparison of 'natural ingredient' with semipurified diets",
abstract = "Three groups of weanling female rats were fed different, commercially available, 'natural ingredient' diets containing 12, 28 or 45 parts/106 F, mainly as bone meal, for six weeks. Two other groups were fed a low-fluoride (0.76 parts/106) semipurified diet. They received fluoride doses, either in the drinking water or by daily intraperitoneal injection, which were approximately equal to the average dose of the other three groups. Rats on the 'natural ingredient' diets ingested more food and water and excreted more faeces arid urine, effects which were attributed to the higher amounts of dietary fibre, Na, K and Cl. Thus, at any given concentration of fluoride in the food or water, the level of fluoride ingestion and the ensuing effects would be influenced by the type of diet used. The values for fractional fluoride absorption (45-49{\%}) and retention (38-47{\%}) were similar among the groups given 'natural ingredient' diets. In the groups given semipurified diet, the corresponding values were about twice as high with the exception that fractional absorption was negative (-41{\%}) in the injected group, which indicated net intestinal secretion of fluoride. Fluoride balances and tissue concentrations were highest in the groups fed the semipurified diet, even though the level of intake was not always higher. The fractional values for calcium and phosphorus absorption (41-51{\%}) and retention (33-43{\%}) were also similar among the groups given 'natural ingredient' diets. The corresponding values were about twice as high in the groups fed the semipurified diet. In terms of supporting maximum bone calcification, phosphorus absorption was marginal in two of the groups on the 'natural ingredient' diets. Because of their variable fluoride concentrations and ill-defined compositions, the use of 'natural ingredient' diets in research should be avoided.",
keywords = "absorption, balance, bone fluoride, bone mineralization, cAMP, dental fluorosis, enamel fluoride, enamel mineralization, faecal excretion, intake, osteoporosis, plasma fluoride, retention, urinary excretion",
author = "Whitford, {G. M.}",
year = "1991",
doi = "10.1016/0003-9969(91)90099-G",
language = "English (US)",
volume = "36",
pages = "291--297",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Fluoride, calcium and phosphorus metabolism in the rat

T2 - Comparison of 'natural ingredient' with semipurified diets

AU - Whitford, G. M.

PY - 1991

Y1 - 1991

N2 - Three groups of weanling female rats were fed different, commercially available, 'natural ingredient' diets containing 12, 28 or 45 parts/106 F, mainly as bone meal, for six weeks. Two other groups were fed a low-fluoride (0.76 parts/106) semipurified diet. They received fluoride doses, either in the drinking water or by daily intraperitoneal injection, which were approximately equal to the average dose of the other three groups. Rats on the 'natural ingredient' diets ingested more food and water and excreted more faeces arid urine, effects which were attributed to the higher amounts of dietary fibre, Na, K and Cl. Thus, at any given concentration of fluoride in the food or water, the level of fluoride ingestion and the ensuing effects would be influenced by the type of diet used. The values for fractional fluoride absorption (45-49%) and retention (38-47%) were similar among the groups given 'natural ingredient' diets. In the groups given semipurified diet, the corresponding values were about twice as high with the exception that fractional absorption was negative (-41%) in the injected group, which indicated net intestinal secretion of fluoride. Fluoride balances and tissue concentrations were highest in the groups fed the semipurified diet, even though the level of intake was not always higher. The fractional values for calcium and phosphorus absorption (41-51%) and retention (33-43%) were also similar among the groups given 'natural ingredient' diets. The corresponding values were about twice as high in the groups fed the semipurified diet. In terms of supporting maximum bone calcification, phosphorus absorption was marginal in two of the groups on the 'natural ingredient' diets. Because of their variable fluoride concentrations and ill-defined compositions, the use of 'natural ingredient' diets in research should be avoided.

AB - Three groups of weanling female rats were fed different, commercially available, 'natural ingredient' diets containing 12, 28 or 45 parts/106 F, mainly as bone meal, for six weeks. Two other groups were fed a low-fluoride (0.76 parts/106) semipurified diet. They received fluoride doses, either in the drinking water or by daily intraperitoneal injection, which were approximately equal to the average dose of the other three groups. Rats on the 'natural ingredient' diets ingested more food and water and excreted more faeces arid urine, effects which were attributed to the higher amounts of dietary fibre, Na, K and Cl. Thus, at any given concentration of fluoride in the food or water, the level of fluoride ingestion and the ensuing effects would be influenced by the type of diet used. The values for fractional fluoride absorption (45-49%) and retention (38-47%) were similar among the groups given 'natural ingredient' diets. In the groups given semipurified diet, the corresponding values were about twice as high with the exception that fractional absorption was negative (-41%) in the injected group, which indicated net intestinal secretion of fluoride. Fluoride balances and tissue concentrations were highest in the groups fed the semipurified diet, even though the level of intake was not always higher. The fractional values for calcium and phosphorus absorption (41-51%) and retention (33-43%) were also similar among the groups given 'natural ingredient' diets. The corresponding values were about twice as high in the groups fed the semipurified diet. In terms of supporting maximum bone calcification, phosphorus absorption was marginal in two of the groups on the 'natural ingredient' diets. Because of their variable fluoride concentrations and ill-defined compositions, the use of 'natural ingredient' diets in research should be avoided.

KW - absorption

KW - balance

KW - bone fluoride

KW - bone mineralization

KW - cAMP

KW - dental fluorosis

KW - enamel fluoride

KW - enamel mineralization

KW - faecal excretion

KW - intake

KW - osteoporosis

KW - plasma fluoride

KW - retention

KW - urinary excretion

UR - http://www.scopus.com/inward/record.url?scp=0025930595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025930595&partnerID=8YFLogxK

U2 - 10.1016/0003-9969(91)90099-G

DO - 10.1016/0003-9969(91)90099-G

M3 - Article

C2 - 1648344

AN - SCOPUS:0025930595

VL - 36

SP - 291

EP - 297

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 4

ER -