Fluoride in whole saliva, parotid ductal saliva and plasma in children

Gary M. Whitford, Jack E. Thomas, Steven M. Adair

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of 100 ml of deionized water. Parotid saliva samples were obtained by use of a Lashley cup. Fluoride concentrations were determined by fluoride ion-specific electrode after diffusion with hexamethyldisiloxane. Rinsing with deionized water did not significantly reduce the fluoride concentration in whole saliva. The whole-saliva fluoride concentrations were not significantly related to those in plasma or parotid ductal saliva. Parotid fluoride concentrations, however, were significantly related to plasma fluoride concentrations (p < 0.0001) by a proportionality constant of 0.80. It was concluded that parotid salivary fluoride concentrations can be used to estimate plasma fluoride concentrations in 5- to 10-year-old children.

Original languageEnglish (US)
Pages (from-to)785-788
Number of pages4
JournalArchives of Oral Biology
Issue number10
StatePublished - Oct 1999


  • Biomarker
  • Fluoride
  • Metabolism
  • Pharmacokinetics
  • Plasma fluoride
  • Salivary fluoride

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology


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