Abstract
The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of 100 ml of deionized water. Parotid saliva samples were obtained by use of a Lashley cup. Fluoride concentrations were determined by fluoride ion-specific electrode after diffusion with hexamethyldisiloxane. Rinsing with deionized water did not significantly reduce the fluoride concentration in whole saliva. The whole-saliva fluoride concentrations were not significantly related to those in plasma or parotid ductal saliva. Parotid fluoride concentrations, however, were significantly related to plasma fluoride concentrations (p < 0.0001) by a proportionality constant of 0.80. It was concluded that parotid salivary fluoride concentrations can be used to estimate plasma fluoride concentrations in 5- to 10-year-old children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 785-788 |
| Number of pages | 4 |
| Journal | Archives of Oral Biology |
| Volume | 44 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 1999 |
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Keywords
- Biomarker
- Fluoride
- Metabolism
- Pharmacokinetics
- Plasma fluoride
- Salivary fluoride
ASJC Scopus subject areas
- Otorhinolaryngology
- Dentistry(all)
- Cell Biology
Cite this
Fluoride in whole saliva, parotid ductal saliva and plasma in children. / Whitford, Gary M.; Thomas, Jack E.; Adair, Steven M.
In: Archives of Oral Biology, Vol. 44, No. 10, 01.10.1999, p. 785-788.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluoride in whole saliva, parotid ductal saliva and plasma in children
AU - Whitford, Gary M.
AU - Thomas, Jack E.
AU - Adair, Steven M.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of 100 ml of deionized water. Parotid saliva samples were obtained by use of a Lashley cup. Fluoride concentrations were determined by fluoride ion-specific electrode after diffusion with hexamethyldisiloxane. Rinsing with deionized water did not significantly reduce the fluoride concentration in whole saliva. The whole-saliva fluoride concentrations were not significantly related to those in plasma or parotid ductal saliva. Parotid fluoride concentrations, however, were significantly related to plasma fluoride concentrations (p < 0.0001) by a proportionality constant of 0.80. It was concluded that parotid salivary fluoride concentrations can be used to estimate plasma fluoride concentrations in 5- to 10-year-old children.
AB - The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of 100 ml of deionized water. Parotid saliva samples were obtained by use of a Lashley cup. Fluoride concentrations were determined by fluoride ion-specific electrode after diffusion with hexamethyldisiloxane. Rinsing with deionized water did not significantly reduce the fluoride concentration in whole saliva. The whole-saliva fluoride concentrations were not significantly related to those in plasma or parotid ductal saliva. Parotid fluoride concentrations, however, were significantly related to plasma fluoride concentrations (p < 0.0001) by a proportionality constant of 0.80. It was concluded that parotid salivary fluoride concentrations can be used to estimate plasma fluoride concentrations in 5- to 10-year-old children.
KW - Biomarker
KW - Fluoride
KW - Metabolism
KW - Pharmacokinetics
KW - Plasma fluoride
KW - Salivary fluoride
UR - http://www.scopus.com/inward/record.url?scp=0033214265&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033214265&partnerID=8YFLogxK
U2 - 10.1016/S0003-9969(99)00083-7
DO - 10.1016/S0003-9969(99)00083-7
M3 - Article
C2 - 10530910
AN - SCOPUS:0033214265
VL - 44
SP - 785
EP - 788
JO - Archives of Oral Biology
JF - Archives of Oral Biology
SN - 0003-9969
IS - 10
ER -