Fluoride metabolism and excretion in children

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This paper compares fluoride pharmacokinetics (plasma, renal, and extrarenal clearances) and metabolic balances in healthy infants or children with those in young or middle-aged adults. Regardless of age, the removal of fluoride from the intra- and extracellular body fluids occurs almost exclusively by uptake in calcified tissues and excretion in the urine. While there can be considerable differences among individuals, the rates at which fluoride is cleared from plasma by calcified tissues and the kidneys in adults are approximately equal. The calcified tissue clearance of fluoride from plasma in children is substantially higher than that by the kidneys. This is due to the greater surface area of the loosely organized crystallites in the developing calcified tissues during growth. Thus, the balance of fluoride (total intake minus total excretion) is typically higher in children than in adults, but it can be positive or negative at any age. Positive balance occurs when chronic fluoride intake is sufficient to prevent plasma concentrations from declining. When positive, the fluoride content of the calcified tissues, which contain more than 99 percent of the body's fluoride, tends to gradually increase. Negative balance, which indicates net mobilization of fluoride from calcified tissues, can occur when plasma concentrations decline due to a reduction in the level of fluoride intake.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalJournal of Public Health Dentistry
Volume59
Issue number4
DOIs
StatePublished - Jan 1 1999

Fingerprint

Fluorides
Kidney
Extracellular Fluid
Body Fluids
Individuality
Pharmacokinetics
Urine
Growth

Keywords

  • Balance
  • Fluoride
  • Metabolism
  • Pharmacokinetics

ASJC Scopus subject areas

  • Dentistry(all)
  • Public Health, Environmental and Occupational Health

Cite this

Fluoride metabolism and excretion in children. / Whitford, Gary M.

In: Journal of Public Health Dentistry, Vol. 59, No. 4, 01.01.1999, p. 224-228.

Research output: Contribution to journalArticle

@article{ffde47edeff5474983a15ef182ef24bd,
title = "Fluoride metabolism and excretion in children",
abstract = "This paper compares fluoride pharmacokinetics (plasma, renal, and extrarenal clearances) and metabolic balances in healthy infants or children with those in young or middle-aged adults. Regardless of age, the removal of fluoride from the intra- and extracellular body fluids occurs almost exclusively by uptake in calcified tissues and excretion in the urine. While there can be considerable differences among individuals, the rates at which fluoride is cleared from plasma by calcified tissues and the kidneys in adults are approximately equal. The calcified tissue clearance of fluoride from plasma in children is substantially higher than that by the kidneys. This is due to the greater surface area of the loosely organized crystallites in the developing calcified tissues during growth. Thus, the balance of fluoride (total intake minus total excretion) is typically higher in children than in adults, but it can be positive or negative at any age. Positive balance occurs when chronic fluoride intake is sufficient to prevent plasma concentrations from declining. When positive, the fluoride content of the calcified tissues, which contain more than 99 percent of the body's fluoride, tends to gradually increase. Negative balance, which indicates net mobilization of fluoride from calcified tissues, can occur when plasma concentrations decline due to a reduction in the level of fluoride intake.",
keywords = "Balance, Fluoride, Metabolism, Pharmacokinetics",
author = "Whitford, {Gary M.}",
year = "1999",
month = "1",
day = "1",
doi = "10.1111/j.1752-7325.1999.tb03273.x",
language = "English (US)",
volume = "59",
pages = "224--228",
journal = "Journal of Public Health Dentistry",
issn = "0022-4006",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Fluoride metabolism and excretion in children

AU - Whitford, Gary M.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - This paper compares fluoride pharmacokinetics (plasma, renal, and extrarenal clearances) and metabolic balances in healthy infants or children with those in young or middle-aged adults. Regardless of age, the removal of fluoride from the intra- and extracellular body fluids occurs almost exclusively by uptake in calcified tissues and excretion in the urine. While there can be considerable differences among individuals, the rates at which fluoride is cleared from plasma by calcified tissues and the kidneys in adults are approximately equal. The calcified tissue clearance of fluoride from plasma in children is substantially higher than that by the kidneys. This is due to the greater surface area of the loosely organized crystallites in the developing calcified tissues during growth. Thus, the balance of fluoride (total intake minus total excretion) is typically higher in children than in adults, but it can be positive or negative at any age. Positive balance occurs when chronic fluoride intake is sufficient to prevent plasma concentrations from declining. When positive, the fluoride content of the calcified tissues, which contain more than 99 percent of the body's fluoride, tends to gradually increase. Negative balance, which indicates net mobilization of fluoride from calcified tissues, can occur when plasma concentrations decline due to a reduction in the level of fluoride intake.

AB - This paper compares fluoride pharmacokinetics (plasma, renal, and extrarenal clearances) and metabolic balances in healthy infants or children with those in young or middle-aged adults. Regardless of age, the removal of fluoride from the intra- and extracellular body fluids occurs almost exclusively by uptake in calcified tissues and excretion in the urine. While there can be considerable differences among individuals, the rates at which fluoride is cleared from plasma by calcified tissues and the kidneys in adults are approximately equal. The calcified tissue clearance of fluoride from plasma in children is substantially higher than that by the kidneys. This is due to the greater surface area of the loosely organized crystallites in the developing calcified tissues during growth. Thus, the balance of fluoride (total intake minus total excretion) is typically higher in children than in adults, but it can be positive or negative at any age. Positive balance occurs when chronic fluoride intake is sufficient to prevent plasma concentrations from declining. When positive, the fluoride content of the calcified tissues, which contain more than 99 percent of the body's fluoride, tends to gradually increase. Negative balance, which indicates net mobilization of fluoride from calcified tissues, can occur when plasma concentrations decline due to a reduction in the level of fluoride intake.

KW - Balance

KW - Fluoride

KW - Metabolism

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=0033182945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033182945&partnerID=8YFLogxK

U2 - 10.1111/j.1752-7325.1999.tb03273.x

DO - 10.1111/j.1752-7325.1999.tb03273.x

M3 - Article

C2 - 10682327

AN - SCOPUS:0033182945

VL - 59

SP - 224

EP - 228

JO - Journal of Public Health Dentistry

JF - Journal of Public Health Dentistry

SN - 0022-4006

IS - 4

ER -