Fluoride Reabsorption by Nonionic Diffusion in the Distal Nephron of the Dog

Gary M. Whitford, David Henry Pashley

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

This study was done to test the hypothesis that fluoride reabsorption is extensive from the distal nephron, the major site for tubular fluid acidification, and to compare the distal nephron handling of fluoride and chloride. Ten stop-flow studies were done in five dogs anesthetized with pentobarbital. Urinary alkalinization was achieved by the intravenous infusion of sodium bicarbonate and acetazolamide or lithium chloride. Acidification was achieved by the infusion of sodium nitrate or sodium sulfate. The results indicate that the extent of fluoride reabsorption from the distal nephron is inversely correlated with urinary pH (P < 0.001). When the urine was strongly acidified by the infusion of sodium sulfate, urine to plasma fluoride concentration ratios were less than 1.0, a finding not previously reported from studies of the renal handling of fluoride. The reabsorption of fluoride from the distal nephron was not correlated consistently with that of chloride. The results indicate that the distal nephron is an important site for the reabsorption of fluoride and they provide additional evidence that HF is the permeating moiety.

Original languageEnglish (US)
Pages (from-to)178-183
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume196
Issue number2
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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