Abstract
Previous studies have shown that chronic acidosis induced by NH4C1 is associated with disturbances in enamel mineralization that resemble severe fluorosis and increased fluoride concentrations in both soft and hard tissues. It has not been shown whether these effects are due to acidosis per se or exposure to high levels of NH+4. This 42-day study with rats fed a low-fluoride diet was done to identify the etiological factor. Two control groups received deionized water or water containing NaCI. Two groups received NH+4-containing compounds that did not produce acidosis (NH4HC03 or HN4 acetate). Two other groups were rendered acidotic by exposure to NH4C1 in the drinking water (metabolic acidosis) or to an atmosphere containing 10% CO2 (respiratory acidosis). The femur epiphysial fluoride concentrations were elevated in the NH4C1 and NH4 acetate groups, and the magnesium concentrations were elevated in the groups exposed to NH4 compounds and in the 10% CCK group. Microradiographic analysis revealed severe disturbances in the mineralization pattern of incisor enamel in both acidotic groups, but normal enamel in the other groups. Enamel fluoride and magnesium concentrations were highest in the acidotic groups. The enamel fluoride concentrations were low (8-14 ppm) and not regarded as the cause of the defective mineralization. It was concluded that the effects on structure and composition of enamel were due to acidosis and not to exposure to high levels of NH+4.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 20-25 |
| Number of pages | 6 |
| Journal | Caries Research |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1995 |
| Externally published | Yes |
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Keywords
- Acid-base balance
- Acidosis
- Amelogenesis
- Ammonium chloride
- Bone
- Enamel
- Fluoride
- Fluorosis
- Magnesium
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Fluorosis-like effects of acidosis, but not nhj, on rat incisor enamel. / Whitford, Gary M.; Angmar-Mansson, B.
In: Caries Research, Vol. 29, No. 1, 01.01.1995, p. 20-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluorosis-like effects of acidosis, but not nhj, on rat incisor enamel
AU - Whitford, Gary M.
AU - Angmar-Mansson, B.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Previous studies have shown that chronic acidosis induced by NH4C1 is associated with disturbances in enamel mineralization that resemble severe fluorosis and increased fluoride concentrations in both soft and hard tissues. It has not been shown whether these effects are due to acidosis per se or exposure to high levels of NH+4. This 42-day study with rats fed a low-fluoride diet was done to identify the etiological factor. Two control groups received deionized water or water containing NaCI. Two groups received NH+4-containing compounds that did not produce acidosis (NH4HC03 or HN4 acetate). Two other groups were rendered acidotic by exposure to NH4C1 in the drinking water (metabolic acidosis) or to an atmosphere containing 10% CO2 (respiratory acidosis). The femur epiphysial fluoride concentrations were elevated in the NH4C1 and NH4 acetate groups, and the magnesium concentrations were elevated in the groups exposed to NH4 compounds and in the 10% CCK group. Microradiographic analysis revealed severe disturbances in the mineralization pattern of incisor enamel in both acidotic groups, but normal enamel in the other groups. Enamel fluoride and magnesium concentrations were highest in the acidotic groups. The enamel fluoride concentrations were low (8-14 ppm) and not regarded as the cause of the defective mineralization. It was concluded that the effects on structure and composition of enamel were due to acidosis and not to exposure to high levels of NH+4.
AB - Previous studies have shown that chronic acidosis induced by NH4C1 is associated with disturbances in enamel mineralization that resemble severe fluorosis and increased fluoride concentrations in both soft and hard tissues. It has not been shown whether these effects are due to acidosis per se or exposure to high levels of NH+4. This 42-day study with rats fed a low-fluoride diet was done to identify the etiological factor. Two control groups received deionized water or water containing NaCI. Two groups received NH+4-containing compounds that did not produce acidosis (NH4HC03 or HN4 acetate). Two other groups were rendered acidotic by exposure to NH4C1 in the drinking water (metabolic acidosis) or to an atmosphere containing 10% CO2 (respiratory acidosis). The femur epiphysial fluoride concentrations were elevated in the NH4C1 and NH4 acetate groups, and the magnesium concentrations were elevated in the groups exposed to NH4 compounds and in the 10% CCK group. Microradiographic analysis revealed severe disturbances in the mineralization pattern of incisor enamel in both acidotic groups, but normal enamel in the other groups. Enamel fluoride and magnesium concentrations were highest in the acidotic groups. The enamel fluoride concentrations were low (8-14 ppm) and not regarded as the cause of the defective mineralization. It was concluded that the effects on structure and composition of enamel were due to acidosis and not to exposure to high levels of NH+4.
KW - Acid-base balance
KW - Acidosis
KW - Amelogenesis
KW - Ammonium chloride
KW - Bone
KW - Enamel
KW - Fluoride
KW - Fluorosis
KW - Magnesium
UR - http://www.scopus.com/inward/record.url?scp=0029180496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029180496&partnerID=8YFLogxK
U2 - 10.1159/000262035
DO - 10.1159/000262035
M3 - Article
VL - 29
SP - 20
EP - 25
JO - Caries Research
JF - Caries Research
SN - 0008-6568
IS - 1
ER -