TY - JOUR
T1 - FMRFamide increases the adenylate cyclase activity and cyclic AMP level of molluscan heart
AU - Higgins, William Joseph
AU - Price, David A.
AU - Greenberg, Michael J.
N1 - Funding Information:
This work was supported in part by N.I.H. Grant HL 0~283 awarded to MIJ. Greenberg and by a Faculty Research Award from the General Research Board, University of Maryland to W.J. Higgins. This is contribution No. 80 from the Tallahassee, Sopchop-py, and Gulf Coast Marine Biological Association.
PY - 1978/4/15
Y1 - 1978/4/15
N2 - FMRFamide (phenylalanyl-methionyl-arginyl-phenylalanine amide) is a cardioexcitatory peptide recently isolated and identified in molluscan ganglia. Both FMRFamide and 5-hydroxytryptamine (5HT), the cardioexcitatory neurotransmitter in molluscs, were tested on the ventricle of the bivalve Mercenaria mercenaria. Both agents increased myocardial contractility, the intracellular cyclic AMP concentration of intact hearts and the adenylate cyclase activity of a myocardial membrane fraction. FMRFamide was 5-10 times more potent than 5HT. All of the effects of 5HT, and none of those of FMRFamide, were blocked by methysergide, a specific 5HT antagonist.
AB - FMRFamide (phenylalanyl-methionyl-arginyl-phenylalanine amide) is a cardioexcitatory peptide recently isolated and identified in molluscan ganglia. Both FMRFamide and 5-hydroxytryptamine (5HT), the cardioexcitatory neurotransmitter in molluscs, were tested on the ventricle of the bivalve Mercenaria mercenaria. Both agents increased myocardial contractility, the intracellular cyclic AMP concentration of intact hearts and the adenylate cyclase activity of a myocardial membrane fraction. FMRFamide was 5-10 times more potent than 5HT. All of the effects of 5HT, and none of those of FMRFamide, were blocked by methysergide, a specific 5HT antagonist.
KW - 5-Hydroxytryptamine
KW - Adenylate cyclase
KW - Cyclic AMP in muscle
KW - FMRFamide
KW - Methysergide
KW - Molluscan heart
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U2 - 10.1016/0014-2999(78)90170-X
DO - 10.1016/0014-2999(78)90170-X
M3 - Article
C2 - 206451
AN - SCOPUS:0018256749
SN - 0014-2999
VL - 48
SP - 425
EP - 430
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 4
ER -