Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery

Medicine & Life Sciences

• Poly(amidoamine) 86%
• Dendrimers 76%
• Folic Acid 55%
• Small Interfering RNA 46%
• Squamous Cell Carcinoma of Head and Neck 20%
• Neoplasms 18%
• Vascular Endothelial Growth Factor A 13%
• Heterografts 5%
• Optical Imaging 3%
• Green Fluorescent Proteins 3%
• Head and Neck Neoplasms 3%
• Microvessels 3%
• Genetic Therapy 2%
• Nanoparticles 2%
• Transfection 2%
• Genes 2%
• Epithelial Cells 2%
• Staining and Labeling 2%
• Growth 1%
• Therapeutics 1%

Engineering & Materials Science

• Dendrimers 100%
• Tumors 57%
• Acids 50%
• Epithelial Cells 37%
• Intercellular Signaling Peptides and Proteins 30%
• Heterografts 14%
• Genes 7%
• Gene therapy 6%
• Fluorescence imaging 6%
• Infrared imaging 4%
• Nanoparticles 3%
• Cells 3%
• Proteins 3%

Chemical Compounds

• Silencing RNA 72%
• Dendrimer 55%
• Intratumorally 26%
• Folate 24%
• Acid 16%
• Near-Infrared Imaging 10%
• PBS Solution 10%
• Size Reduction 8%
• Folic Acid 8%
• Antitumor 6%
• Dose 5%
• Fluorescence 4%
• Nanoparticle 3%
• Reduction 3%