Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study

Frank Angenstein, Elena Kammerer, Heiko G. Niessen, Julietta Uta Frey, Henning Scheich, Sabine Martina Frey

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Frequency-dependent hippocampal activation during electrical perforant pathway stimulation was analyzed simultaneously by electrophysiological recordings in dentate gyrus and functional magnetic resonance imaging (fMRI). Pulse trains at low-frequency stimulation (2.5 Hz) did not influence electrophysiological responses within stimulation trains in the dentate gyrus and triggered no detectable BOLD responses. Increased stimulation frequencies (5.0-20 Hz) generated a roughly linear enhancement of the BOLD response. The BOLD signal within the dentate gyrus correlated more closely with stimulus pattern than with generated action potentials of the granular cells. However, the BOLD signal was strongly influenced by additional local signal processing activated by repetitive stimulus trains. fMRI visualized a frequency-specific spatial activation pattern of the hippocampus; spatially restricted activation in the dentate gyrus during 5-Hz stimulation, activation of the entire hippocampus and subiculum at 10 Hz and activation of the contralateral hippocampus during 20-Hz stimulation.

Original languageEnglish (US)
Pages (from-to)150-163
Number of pages14
JournalNeuroImage
Volume38
Issue number1
DOIs
StatePublished - Oct 15 2007

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Dentate Gyrus
Hippocampus
Magnetic Resonance Imaging
Perforant Pathway
Action Potentials

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Angenstein, F., Kammerer, E., Niessen, H. G., Frey, J. U., Scheich, H., & Frey, S. M. (2007). Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study. NeuroImage, 38(1), 150-163. https://doi.org/10.1016/j.neuroimage.2007.07.022

Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study. / Angenstein, Frank; Kammerer, Elena; Niessen, Heiko G.; Frey, Julietta Uta; Scheich, Henning; Frey, Sabine Martina.

In: NeuroImage, Vol. 38, No. 1, 15.10.2007, p. 150-163.

Research output: Contribution to journalArticle

Angenstein, F, Kammerer, E, Niessen, HG, Frey, JU, Scheich, H & Frey, SM 2007, 'Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study', NeuroImage, vol. 38, no. 1, pp. 150-163. https://doi.org/10.1016/j.neuroimage.2007.07.022
Angenstein, Frank ; Kammerer, Elena ; Niessen, Heiko G. ; Frey, Julietta Uta ; Scheich, Henning ; Frey, Sabine Martina. / Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study. In: NeuroImage. 2007 ; Vol. 38, No. 1. pp. 150-163.
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