Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study

Frank Angenstein; Elena Kammerer; Heiko G. Niessen; Julietta U. Frey; Henning Scheich; Sabine Frey

doi:10.1016/j.neuroimage.2007.07.022

Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study

Frank Angenstein, Elena Kammerer, Heiko G. Niessen, Julietta U. Frey, Henning Scheich, Sabine Frey

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Frequency-dependent hippocampal activation during electrical perforant pathway stimulation was analyzed simultaneously by electrophysiological recordings in dentate gyrus and functional magnetic resonance imaging (fMRI). Pulse trains at low-frequency stimulation (2.5 Hz) did not influence electrophysiological responses within stimulation trains in the dentate gyrus and triggered no detectable BOLD responses. Increased stimulation frequencies (5.0-20 Hz) generated a roughly linear enhancement of the BOLD response. The BOLD signal within the dentate gyrus correlated more closely with stimulus pattern than with generated action potentials of the granular cells. However, the BOLD signal was strongly influenced by additional local signal processing activated by repetitive stimulus trains. fMRI visualized a frequency-specific spatial activation pattern of the hippocampus; spatially restricted activation in the dentate gyrus during 5-Hz stimulation, activation of the entire hippocampus and subiculum at 10 Hz and activation of the contralateral hippocampus during 20-Hz stimulation.

Original language	English (US)
Pages (from-to)	150-163
Number of pages	14
Journal	NeuroImage
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroimage.2007.07.022
State	Published - Oct 15 2007

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2007.07.022

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abstract = "Frequency-dependent hippocampal activation during electrical perforant pathway stimulation was analyzed simultaneously by electrophysiological recordings in dentate gyrus and functional magnetic resonance imaging (fMRI). Pulse trains at low-frequency stimulation (2.5 Hz) did not influence electrophysiological responses within stimulation trains in the dentate gyrus and triggered no detectable BOLD responses. Increased stimulation frequencies (5.0-20 Hz) generated a roughly linear enhancement of the BOLD response. The BOLD signal within the dentate gyrus correlated more closely with stimulus pattern than with generated action potentials of the granular cells. However, the BOLD signal was strongly influenced by additional local signal processing activated by repetitive stimulus trains. fMRI visualized a frequency-specific spatial activation pattern of the hippocampus; spatially restricted activation in the dentate gyrus during 5-Hz stimulation, activation of the entire hippocampus and subiculum at 10 Hz and activation of the contralateral hippocampus during 20-Hz stimulation.",

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AU - Scheich, Henning

AU - Frey, Sabine

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Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study

Abstract

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