Functional differences in human neutrophils isolated pre- and post-prandially

David J. Uhlinger, David N. Burnham, Richard E. Mullins, John R. Kalmar, Christopher W Cutler, Roland R. Arnold, J. David Lambeth, Alfred H. Merrill

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Activated polymorphonuclear leukocytes have been associated with neoplasia, atherogenesis and reperfusion injury. Since some of these conditions are also correlated with dietary fat, we examined the functional characteristics of leukocytes isolated from subjects before and after consumption of a lipid-rich meal. There was up to 2-fold greater superoxide generation in response to agonists in leukocytes obtained post-prandially; the maximum increase was observed about 4 h after eating and followed the peak (2-4 h) in serum triglycerides. Neutrophils isolated post-prandially also exhibited impaired chemotaxis and defective bacterial killing, but normal phagocytosis. These findings provide a new variable that should be considered in studies of leukocytes.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalFEBS Letters
Volume286
Issue number1-2
DOIs
StatePublished - Jul 29 1991
Externally publishedYes

Fingerprint

Dietary Fats
Superoxides
Triglycerides
Neutrophils
Leukocytes
Lipids
Chemotaxis
Reperfusion Injury
Phagocytosis
Meals
Atherosclerosis
Eating
Serum
Neoplasms

Keywords

  • Chemotaxis
  • Diet
  • Lipoprotein
  • Neutrophil
  • Respiratory burst

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Uhlinger, D. J., Burnham, D. N., Mullins, R. E., Kalmar, J. R., Cutler, C. W., Arnold, R. R., ... Merrill, A. H. (1991). Functional differences in human neutrophils isolated pre- and post-prandially. FEBS Letters, 286(1-2), 28-32. https://doi.org/10.1016/0014-5793(91)80933-T

Functional differences in human neutrophils isolated pre- and post-prandially. / Uhlinger, David J.; Burnham, David N.; Mullins, Richard E.; Kalmar, John R.; Cutler, Christopher W; Arnold, Roland R.; Lambeth, J. David; Merrill, Alfred H.

In: FEBS Letters, Vol. 286, No. 1-2, 29.07.1991, p. 28-32.

Research output: Contribution to journalArticle

Uhlinger, DJ, Burnham, DN, Mullins, RE, Kalmar, JR, Cutler, CW, Arnold, RR, Lambeth, JD & Merrill, AH 1991, 'Functional differences in human neutrophils isolated pre- and post-prandially', FEBS Letters, vol. 286, no. 1-2, pp. 28-32. https://doi.org/10.1016/0014-5793(91)80933-T
Uhlinger DJ, Burnham DN, Mullins RE, Kalmar JR, Cutler CW, Arnold RR et al. Functional differences in human neutrophils isolated pre- and post-prandially. FEBS Letters. 1991 Jul 29;286(1-2):28-32. https://doi.org/10.1016/0014-5793(91)80933-T
Uhlinger, David J. ; Burnham, David N. ; Mullins, Richard E. ; Kalmar, John R. ; Cutler, Christopher W ; Arnold, Roland R. ; Lambeth, J. David ; Merrill, Alfred H. / Functional differences in human neutrophils isolated pre- and post-prandially. In: FEBS Letters. 1991 ; Vol. 286, No. 1-2. pp. 28-32.
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