Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model

J. M. Kloss, D. S. Utley, D. J. Terris, D. H. Sierra

Research output: Contribution to conferencePaper

Abstract

The rat sciatic nerve model was employed to evaluate collagen and brain derived neurotrophic factor (BDNF) used for peripheral nerve regeneration. The collagen tubule (CT)/linked-BDNF repair group demonstrated a statistically significant superior functional recovery compared to epineural coaptation (EC). Moreover CT/pumped-BDNF showed enhanced functional recovery compared to CT and EC. The CT/linked-BDNF repair group showed the largest mean axon diameters proximal and distal to the repair site. Repair groups that included both collagen tubulization and BDNF delivery improved the rate and the degree to which recovery of sciatic function occurs after nerve transection and repair.

Original languageEnglish (US)
Number of pages1
Publication statusPublished - Dec 1 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Kloss, J. M., Utley, D. S., Terris, D. J., & Sierra, D. H. (1996). Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .