Functionalized Diphenyl-Imidazolo-Pyrimidines

Pavel P. Lyubashov; Vyacheslav M. Povstyanoy; Andrey A. Krysko; Alexander Plotkin; Ilene Lovett; Mykhailo V. Povstyaniy; Iryna O. Lebedyeva

doi:10.1002/jhet.3044

Functionalized Diphenyl-Imidazolo-Pyrimidines

Pavel P. Lyubashov, Vyacheslav M. Povstyanoy, Andrey A. Krysko, Alexander Plotkin, Ilene Lovett, Mykhailo V. Povstyaniy, Iryna O. Lebedyeva

Research output: Contribution to journal › Article › peer-review

Abstract

Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N-nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.

Original language	English (US)
Pages (from-to)	276-281
Number of pages	6
Journal	Journal of Heterocyclic Chemistry
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/jhet.3044
State	Published - Jan 2018
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "Functionalized Diphenyl-Imidazolo-Pyrimidines",

abstract = "Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N-nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.",

author = "Lyubashov, {Pavel P.} and Povstyanoy, {Vyacheslav M.} and Krysko, {Andrey A.} and Alexander Plotkin and Ilene Lovett and Povstyaniy, {Mykhailo V.} and Lebedyeva, {Iryna O.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2018",

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doi = "10.1002/jhet.3044",

language = "English (US)",

volume = "55",

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T1 - Functionalized Diphenyl-Imidazolo-Pyrimidines

AU - Lyubashov, Pavel P.

AU - Povstyanoy, Vyacheslav M.

AU - Krysko, Andrey A.

AU - Plotkin, Alexander

AU - Lovett, Ilene

AU - Povstyaniy, Mykhailo V.

AU - Lebedyeva, Iryna O.

PY - 2018/1

Y1 - 2018/1

N2 - Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N-nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.

AB - Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N-nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.

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DO - 10.1002/jhet.3044

M3 - Article

AN - SCOPUS:85033701977

SN - 0022-152X

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EP - 281

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 1

ER -

Functionalized Diphenyl-Imidazolo-Pyrimidines

Abstract

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