Functionalized Diphenyl-Imidazolo-Pyrimidines

Pavel P. Lyubashov, Vyacheslav M. Povstyanoy, Andrey A. Krysko, Alexander Plotkin, Ilene Lovett, Mykhailo V. Povstyaniy, Iryna Oleksandrivna Lebedyeva

Research output: Contribution to journalArticle

Abstract

Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N-nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume55
Issue number1
DOIs
StatePublished - Jan 1 2018

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Bromine
Pyrimidines
Nucleophiles
Amides
diphenyl
imidazole
pyrimidine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Lyubashov, P. P., Povstyanoy, V. M., Krysko, A. A., Plotkin, A., Lovett, I., Povstyaniy, M. V., & Lebedyeva, I. O. (2018). Functionalized Diphenyl-Imidazolo-Pyrimidines. Journal of Heterocyclic Chemistry, 55(1), 276-281. https://doi.org/10.1002/jhet.3044

Functionalized Diphenyl-Imidazolo-Pyrimidines. / Lyubashov, Pavel P.; Povstyanoy, Vyacheslav M.; Krysko, Andrey A.; Plotkin, Alexander; Lovett, Ilene; Povstyaniy, Mykhailo V.; Lebedyeva, Iryna Oleksandrivna.

In: Journal of Heterocyclic Chemistry, Vol. 55, No. 1, 01.01.2018, p. 276-281.

Research output: Contribution to journalArticle

Lyubashov, PP, Povstyanoy, VM, Krysko, AA, Plotkin, A, Lovett, I, Povstyaniy, MV & Lebedyeva, IO 2018, 'Functionalized Diphenyl-Imidazolo-Pyrimidines', Journal of Heterocyclic Chemistry, vol. 55, no. 1, pp. 276-281. https://doi.org/10.1002/jhet.3044
Lyubashov PP, Povstyanoy VM, Krysko AA, Plotkin A, Lovett I, Povstyaniy MV et al. Functionalized Diphenyl-Imidazolo-Pyrimidines. Journal of Heterocyclic Chemistry. 2018 Jan 1;55(1):276-281. https://doi.org/10.1002/jhet.3044
Lyubashov, Pavel P. ; Povstyanoy, Vyacheslav M. ; Krysko, Andrey A. ; Plotkin, Alexander ; Lovett, Ilene ; Povstyaniy, Mykhailo V. ; Lebedyeva, Iryna Oleksandrivna. / Functionalized Diphenyl-Imidazolo-Pyrimidines. In: Journal of Heterocyclic Chemistry. 2018 ; Vol. 55, No. 1. pp. 276-281.
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