Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder

Michael A. Hauser, Melanie E. Garrett, Yutao Liu, Michelle F. Dennis, Nathan A. Kimbrel, Affairs Mid-Atlantic Mental Illness Research, Education, Veterans Affairs Mid-Atlantic Mental Illness Research, Education,, Jean C. Beckham, Allison E. Ashley-Koch

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The aim of the present study was to attempt to replicate the recently reported finding associating rs2400707 of the Adrenoceptor Beta 2, Surface (ADRB2) gene and childhood trauma on PTSD symptoms. Participants included a predominantly veteran cohort of non-Hispanic blacks (NHB; n = 949) and a pre-dominantly veteran cohort of non-Hispanic whites (NHW; n = 759). No main effects were observed for rs2400707 on PTSD diagnosis. Among the NHB participants, we observed an interaction between rs2400707 and history of childhood trauma, whereby with each additional A allele, the odds of having PTSD increased by 1.31, but only among those who had experienced childhood trauma (p = 0.038). The interaction with rs2400707 and childhood trauma was not observed among the NHW study participants (p = 0.892). Taken together, the findings from the present research provide further evidence that the adrenergic system may be an important modulator of PTSD risk; however, additional work is still needed to clarify the exact nature of the relationship between PTSD and rs2400707 of the ADRB2 gene.

Original languageEnglish (US)
Pages (from-to)59-61
Number of pages3
JournalJournal of Psychiatric Research
Volume84
DOIs
StatePublished - Jan 1 2017

Keywords

  • ADRB2
  • Childhood trauma
  • MIRECC
  • PTSD
  • Posttraumatic stress disorder
  • VA
  • Veterans

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Hauser, M. A., Garrett, M. E., Liu, Y., Dennis, M. F., Kimbrel, N. A., Veterans Affairs Mid-Atlantic Mental Illness Research, Education, A. M-A. M. I. R. E., Beckham, J. C., & Ashley-Koch, A. E. (2017). Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder. Journal of Psychiatric Research, 84, 59-61. https://doi.org/10.1016/j.jpsychires.2016.09.013