@article{f1e8942b6dd440159634ee7a6e70aff0,
title = "Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder",
abstract = "The aim of the present study was to attempt to replicate the recently reported finding associating rs2400707 of the Adrenoceptor Beta 2, Surface (ADRB2) gene and childhood trauma on PTSD symptoms. Participants included a predominantly veteran cohort of non-Hispanic blacks (NHB; n = 949) and a pre-dominantly veteran cohort of non-Hispanic whites (NHW; n = 759). No main effects were observed for rs2400707 on PTSD diagnosis. Among the NHB participants, we observed an interaction between rs2400707 and history of childhood trauma, whereby with each additional A allele, the odds of having PTSD increased by 1.31, but only among those who had experienced childhood trauma (p = 0.038). The interaction with rs2400707 and childhood trauma was not observed among the NHW study participants (p = 0.892). Taken together, the findings from the present research provide further evidence that the adrenergic system may be an important modulator of PTSD risk; however, additional work is still needed to clarify the exact nature of the relationship between PTSD and rs2400707 of the ADRB2 gene.",
keywords = "ADRB2, Childhood trauma, MIRECC, PTSD, Posttraumatic stress disorder, VA, Veterans",
author = "Hauser, {Michael A.} and Garrett, {Melanie E.} and Yutao Liu and Dennis, {Michelle F.} and Kimbrel, {Nathan A.} and {Veterans Affairs Mid-Atlantic Mental Illness Research, Education,}, {Affairs Mid-Atlantic Mental Illness Research, Education,} and Beckham, {Jean C.} and Ashley-Koch, {Allison E.}",
note = "Funding Information: This project was supported in part by the Department of Veterans Affairs{\textquoteright} (VA) Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC) of the VA Office of Mental Health Services, the VA VISN 6 Mid-Atlantic Healthcare Network , and Durham Veterans Affairs Medical Center . Dr. Kimbrel was supported by a Career Development Award (IK2 CX000525) from the Clinical Science Research and Development (CSR&D) Service of the VA Office of Research and Development (ORD). Dr. Beckham was supported by a Research Career Scientist Award from the CSR&D Service of the VA ORD . VA CSR&D played no role in study design, data collection, data analysis, manuscript preparation, or the decision to submit this article for publication. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the VA or the United States government. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2017",
month = jan,
day = "1",
doi = "10.1016/j.jpsychires.2016.09.013",
language = "English (US)",
volume = "84",
pages = "59--61",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
}
