Further Observations on Cerebral or Retinal Ischemia in Patients With Right-Left Intracardiac Shunts

José Biller, Maryl R. Johnson, Harold P. Adams, Richard E. Kerber, James J. Corbett, Askiel Bruno, Richard J. Leth

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Between October 1983 and November 1986, 20 patients suspected of having a paradoxical cerebral or retinal embolism were identified. Cerebral infarction was the most common presentation. Six patients had a patent foramen ovale demonstrated by cardiac catheterization or surgery. Three patients had a newly discovered atrial septal defect, and one had an atrial septal defect that had previously been treated surgically. Results of the cardiac physical examination, chest roentgenography, and electrocardiography were unremarkable in 12 patients. Eighteen patients had a right-to-left shunt demonstrated by contrast echocardiography. Nine of these patients underwent cardiac catheterization; seven had abnormal catheterization study results: four had a patent foramen ovale and three had an atrial septal defect. Sixteen patients received medical therapy only while four underwent surgery. All patients survived the initial insult. There were no deaths or ischemic recurrences on follow-up ranging from one month to three years. We believe that contrast echocardiography can provide important diagnostic information, even in situations in which cardiac involvement is not suspected. Additional studies are needed before the optimal treatment of presumptive paradoxical cerebral embolism can be determined.

Original languageEnglish (US)
Pages (from-to)740-743
Number of pages4
JournalArchives of Neurology
Volume44
Issue number7
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Patient Rights
Ischemia
Atrial Heart Septal Defects
Patent Foramen Ovale
Cardiac Catheterization
Echocardiography
Paradoxical Embolism
Intracranial Embolism
Cerebral Infarction
Embolism
Radiography
Catheterization
Thoracic Surgery
Physical Examination
Electrocardiography
Thorax
Recurrence
Therapeutics
Defects

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Further Observations on Cerebral or Retinal Ischemia in Patients With Right-Left Intracardiac Shunts. / Biller, José; Johnson, Maryl R.; Adams, Harold P.; Kerber, Richard E.; Corbett, James J.; Bruno, Askiel; Leth, Richard J.

In: Archives of Neurology, Vol. 44, No. 7, 01.01.1987, p. 740-743.

Research output: Contribution to journalArticle

Biller, José ; Johnson, Maryl R. ; Adams, Harold P. ; Kerber, Richard E. ; Corbett, James J. ; Bruno, Askiel ; Leth, Richard J. / Further Observations on Cerebral or Retinal Ischemia in Patients With Right-Left Intracardiac Shunts. In: Archives of Neurology. 1987 ; Vol. 44, No. 7. pp. 740-743.
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