Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma

Ken C. Lo, Changxing Ma, Brian N. Bundy, Scott L. Pomeroy, Charles G. Eberhart, John K. Cowell

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: Tumor risk stratification during diagnosis is paramount for children with medulloblastomas, primarily because very young patients (<3 years) suffer cognitive deficits from radio- and chemotherapy sequelae. Thus, distinguishing tumors that are biologically more aggressive is essential for medulloblastoma management to maximize the delay in radiation treatment without adversely affecting survival outcome. In this context, current strategies for risk assessment, which are based on clinical parameters, remain unsatisfactory. Experimental Design: Array-based comparative genomic hybridization (aCGH) was used to identify chromosomal copy number abnormalities in a cohort of 49 medulloblastoma tumors. Basedon the karyotypes generated from a CGH analysis, each tumorwas scored for copy number abnormalities, and the log-rank test was used to evaluate whether any cytogenetic events were associated with survival. Results: A single copy gain of 1q was shown to be a negative prognostic marker for survival in medulloblastomas with high statistical significance (P < 0.0001, log-rank test). Conclusion: A gain of 1q provides a potential means of predicting overall survival in medulloblastoma.

Original languageEnglish (US)
Pages (from-to)7022-7028
Number of pages7
JournalClinical Cancer Research
Volume13
Issue number23
DOIs
StatePublished - Dec 1 2007

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Medulloblastoma
Survival
Neoplasms
Comparative Genomic Hybridization
Karyotype
Cytogenetics
Research Design
Radiotherapy
Radiation
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. / Lo, Ken C.; Ma, Changxing; Bundy, Brian N.; Pomeroy, Scott L.; Eberhart, Charles G.; Cowell, John K.

In: Clinical Cancer Research, Vol. 13, No. 23, 01.12.2007, p. 7022-7028.

Research output: Contribution to journalArticle

Lo, Ken C. ; Ma, Changxing ; Bundy, Brian N. ; Pomeroy, Scott L. ; Eberhart, Charles G. ; Cowell, John K. / Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. In: Clinical Cancer Research. 2007 ; Vol. 13, No. 23. pp. 7022-7028.
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AU - Eberhart, Charles G.

AU - Cowell, John K.

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AB - Purpose: Tumor risk stratification during diagnosis is paramount for children with medulloblastomas, primarily because very young patients (<3 years) suffer cognitive deficits from radio- and chemotherapy sequelae. Thus, distinguishing tumors that are biologically more aggressive is essential for medulloblastoma management to maximize the delay in radiation treatment without adversely affecting survival outcome. In this context, current strategies for risk assessment, which are based on clinical parameters, remain unsatisfactory. Experimental Design: Array-based comparative genomic hybridization (aCGH) was used to identify chromosomal copy number abnormalities in a cohort of 49 medulloblastoma tumors. Basedon the karyotypes generated from a CGH analysis, each tumorwas scored for copy number abnormalities, and the log-rank test was used to evaluate whether any cytogenetic events were associated with survival. Results: A single copy gain of 1q was shown to be a negative prognostic marker for survival in medulloblastomas with high statistical significance (P < 0.0001, log-rank test). Conclusion: A gain of 1q provides a potential means of predicting overall survival in medulloblastoma.

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